Biomarkers of free radical damage applications in experimental animals and in humans

被引：659
作者：
De Zwart, LL [1 ]
Meerman, JHN [1 ]
Commandeur, JNM [1 ]
Vermeulen, NPE [1 ]
机构：
[1] Free Univ Amsterdam, Dept Pharmacochem, Leiden Amsterdam Ctr Drug Res, Div Mol Toxicol, NL-1081 HV Amsterdam, Netherlands
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 1999年 / 26卷 / 1-2期
关键词：
free radical; non-invasive biomarkers; lipid peroxidation; isoprostanes; alkanes; aldehydic products; DNA hydroxylation; protein oxidation;
D O I：
10.1016/S0891-5849(98)00196-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Free radical damage is an important factor in many pathological and toxicological processes. Despite extensive research efforts in biomarkers in recent years, yielding promising results in experimental animals, there is still a great need for additional research on the applicability of, especially non-invasive, biomarkers of free radical damage in humans. This review gives an overview of the applications in experimental and human situations of four main groups of products resulting from free radical damage, these include: lipid peroxidation products, isoprostanes, DNA-hydroxylation products and protein hydroxylation products. (C) 1998 Elsevier Science Inc.
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页码：202 / 226
页数：25
相关论文
共 226 条
[1]   OXYGEN FREE-RADICALS AND PARKINSONS-DISEASE [J].
ADAMS, JD ;
ODUNZE, IN .
FREE RADICAL BIOLOGY AND MEDICINE, 1991, 10 (02) :161-169
[2]   OXIDATIVE DAMAGE TO DNA - RELATION TO SPECIES METABOLIC-RATE AND LIFE-SPAN [J].
ADELMAN, R ;
SAUL, RL ;
AMES, BN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2706-2708
[3]  
AKUBUE PI, 1993, B ENVIRON CONTAM TOX, V50, P565, DOI 10.1007/BF00191247
[4]  
ALLERHEILIGEN SRB, 1987, DRUG METAB DISPOS, V15, P794
[5]   ENDOGENOUS MUTAGENS AND THE CAUSES OF AGING AND CANCER [J].
AMES, BN ;
GOLD, LS .
MUTATION RESEARCH, 1991, 250 (1-2) :3-16
[6]  
AMES BN, 1985, GENETIC TOXICOLOGY E, P1
[7]  
[Anonymous], 1982, FREE RADIC LIPID PER
[8]  
ARTERBERY VE, 1994, FREE RADICAL BIO MED, V17, P569
[9]  
AWAD JA, 1995, HEPATOLOGY, V22, P962, DOI 10.1016/0270-9139(95)90321-6
[10]  
AWAD JA, 1994, J PHARMACOL EXP THER, V270, P858
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