Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C-O Bonds

被引：41
|
作者：
Zeng, Xiaoqin [1 ]
Zhang, Yuxuan [1 ]
Liu, Zhengli [1 ]
Geng, Shasha [1 ]
He, Yun [1 ]
Feng, Zhang [1 ,2 ,3 ]
机构：
[1] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China
[2] North Sichuan Med Coll, Sch Preclin Med, Sichuan Key Lab Med Imaging, Nanchong 637000, Sichuan, Peoples R China
[3] North Sichuan Med Coll, Dept Chem, Nanchong 637000, Sichuan, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 08期
关键词：
CROSS-COUPLING REACTIONS; 2-PYRIDYL ETHERS; CARBON-OXYGEN; DIFLUOROMETHYLATED ARENES; H BORYLATION; ACTIVATION; ALKYL; NI; FUNCTIONALIZATION; HYDROBORATION;
D O I：
10.1021/acs.orglett.0c00679
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the iron-catalyzed borylation of aryl ethers and aryl amines via deavage of C-O and C-N bonds. This protocol does not require the use of Grignard reagents and displays a broad substrate scope, which allows the late-stage borylation. It also provides facile access to multisubstituted arenes through C-H fiinctionalization using 2-pyridyloxy as the directing group.
引用
收藏
页码：2950 / 2955
页数：6
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