Optimization of the experimental parameters in the determination of lamotrigine by adsorptive stripping voltammetry

This paper describes a procedure that has been optimized for the determination of lamotrigine (LTG) by adsorptive stripping voltammetry (AdSV). Two different voltammetric techniques, namely differential pulse adsorptive stripping voltammetry (DPAdSV) and square wave adsorptive stripping voltammetry (SWAdSV) were used. In order to determine the most sensitive technique, optimization of the experimental parameters using experimental design methodology was carried out for each technique. The detection limits obtained, 4.68 x 10(-9) mol dm (-3) for DPAdSV and 5.02 x 10(-9) mol dm (-3) for SWAdSV, show that both techniques are almost the same sensitive for the analysis of lamotrigine. Finally, this method was used to determine lamotrigine in pharmaceutical preparations and in spiked human plasma samples. (c) 2005 Elsevier B.V. All rights reserved.