Glutamate and GABA in lateral hypothalamic mechanisms controlling food intake

被引:88
|
作者
Stanley, B. G. [1 ,2 ]
Urstadt, K. R. [1 ]
Charles, J. R. [3 ]
Kee, T. [1 ]
机构
[1] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA
[2] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA
[3] Univ Calif Riverside, Grad Program Neurosci, Riverside, CA 92521 USA
关键词
Lateral hypothalamus; Glutamate; Gamma aminobutyric acid; Eating behavior; Body weight; MELANIN-CONCENTRATING HORMONE; NUCLEUS-ACCUMBENS SHELL; D-ASPARTIC ACID; VENTRAL TEGMENTAL AREA; DECREASES EXTRACELLULAR DOPAMINE; FEEDING-BEHAVIOR; NEUROPEPTIDE-Y; REVERSE MICRODIALYSIS; SELF-STIMULATION; KAINATE RECEPTORS;
D O I
10.1016/j.physbeh.2011.04.046
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
By the 1990s a convergence of evidence had accumulated to suggest that neurons within the lateral hypothalamus (LH) play important roles in the stimulation of feeding behavior. However, there was little direct evidence demonstrating that neurotransmitters in the LH could, like electrical stimulation, elicit feeding in satiated animals. The present paper is a brief review in honor of Bartley Hoebel's scientific contributions, emphasizing the evidence from my lab that the excitatory neurotransmitter glutamate and the inhibitory neurotransmitter gamma aminobutyric acid (GABA),in the LH mediate feeding stimulation and feeding inhibition respectively. Specifically, we summarize evidence that LH injection of glutamate, or agonists of its N-methyl-D-aspartate (NMDA) and non-NMDA receptors, elicits feeding in satiated rats, that NMDA receptor antagonists block the eating elicited by NMDA and, more importantly, that NMDA blockade suppresses natural feeding and can reduce body weight. Conversely, GABA(A) agonists injected into the LH suppress feeding and can also reduce body weight, while GABA(A) receptor antagonists actually elicit eating when injected into the LH of satiated rats. It is suggested that natural feeding may reflect the moment-to-moment balance in the activity of glutamate and GABA within the LH. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:40 / 46
页数:7
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