Development of NAMI-A-loaded PLGA-mPEG Nanoparticles: Physicochemical Characterization, in vitro Drug Release and in vivo Antitumor Efficacy

被引：0

作者：

Yang Yong-guang ^{[2
]}

Liu Du ^{[2
]}

Xia Yu ^{[2
]}

Zhou Yan-hui ^{[2
]}

Zhong Xue-yun ^{[1
]}

Liu Jie ^{[2
]}

机构：

[1] Jinan Univ, Coll Med, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, Dept Chem, Guangzhou 510632, Guangdong, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2011年 / 27卷 / 03期

基金：

中国国家自然科学基金;

关键词：

PLGA-mPEG nanoparticle; NAMI-A; Drug release; Drug delivery; Antitumor; DELIVERY; CISPLATIN; EFFICIENCY; COMPLEXES; POLYMERS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NAMI-A[imidazolium trans-tetrachloro(dimethylsulfoxide)imidazoleruthenium(III)]. shows extraordinary activities against metastatic tumors. However, the hydrolysis of NAMI-A to produce dimethyl sulfoxide(DMSO) could reduce anti-metastatic activity. To enhance the circulation time and the anti-metastatic effect of NAMI-A, NAMI-A-loaded nanoparticles were prepared by the double emulsion method and characterized by scanning electron microscopy for surface morphology, laser light scattering rot size and zeta potential for surface charges. Controlled release of NAMI-A was observed in a sustained manner. Compared with free NAMI-A, NAMI-A-loaded nanoparticles exhibited superior antitumor effect by delaying tumor growth in T739 mice. PLGA-mPEG nanoparticles are promising for further studies as drug delivery carriers.

引用

页码：345 / 349

页数：5

共 29 条

[1] SYNTHESIS, MOLECULAR-STRUCTURE, AND CHEMICAL BEHAVIOR OF HYDROGEN TRANS-BIS(DIMETHYL SULFOXIDE)TETRACHLORORUTHENATE(III) AND MER-TRICHLOROTRIS(DIMETHYL SULFOXIDE)RUTHENIUM(III) - THE 1ST FULLY CHARACTERIZED CHLORIDE DIMETHYL-SULFOXIDE RUTHENIUM(III) COMPLEXES
ALESSIO, E
BALDUCCI, G
CALLIGARIS, M
COSTA, G
ATTIA, WM
MESTRONI, G
[J]. INORGANIC CHEMISTRY, 1991, 30 (04) : 609 - 618
[2] PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in Vivo drug residence in blood properties
Avgoustakis, K
Beletsi, A
Panagi, Z
Klepetsanis, P
Karydas, AG
Ithakissios, DS
[J]. JOURNAL OF CONTROLLED RELEASE, 2002, 79 (1-3) : 123 - 135
[3] Functional polymers in drug delivery: carrier-supported CDDP (cis-platin) complexes of polycarboxylates - effect on human ovarian carcinoma
Avichezer, D
Schechter, B
Arnon, R
[J]. REACTIVE & FUNCTIONAL POLYMERS, 1998, 36 (01) : 59 - 69
[4] Effect of preparative variables on the properties of poly(dl-lactide-co-glycolide) methoxypoly(ethyleneglycol) copolymers related to their application in controlled drug delivery
Beletsi, A
Leontiadis, L
Klepetsanis, P
Ithakissios, DS
Avgoustakis, K
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 182 (02) : 187 - 197
[5] Effects of NAMI-A and some related ruthenium complexes on cell viability after short exposure of tumor cells
Bergamo, A
Zorzet, S
Gava, B
Sorc, A
Alessio, E
Iengo, E
Sava, G
[J]. ANTI-CANCER DRUGS, 2000, 11 (08) : 665 - 672
[6] Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells
Chen, Tianfeng
Liu, Yanan
Zheng, Wen-Jie
Liu, Jie
Wong, Yum-Shing
[J]. INORGANIC CHEMISTRY, 2010, 49 (14) : 6366 - 6368
[7] Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs
Dong, YC
Feng, SS
[J]. BIOMATERIALS, 2004, 25 (14) : 2843 - 2849
[8] Nonoparticles of biodegradable polymers for new-concept chemotherapy
Feng, SS
[J]. EXPERT REVIEW OF MEDICAL DEVICES, 2004, 1 (01) : 115 - 125
[9] Ferruti P, 1999, MACROMOL CHEM PHYS, V200, P1644
[10] GHOBAD M, 2010, COLLOID SURFACE B, V80, P34

← 1 2 3 →