CuBr-Catalyzed α-Arylation and Aerobic Oxidative Dehydrogenative C-N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-one Derivatives

被引：15

作者：

Dong, Fang ^{[1
]}

Liu, Jian-Quan ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synth Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 08期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

H AMINATION; CYCLIZATION; ACTIVATION; AMIDATION; DISCOVERY; PHENOLS; POTENT; BONDS;

D O I：

10.1021/acs.orglett.0c00497

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed approach was disclosed for C(sp(3))-C(sp(2)) bond formation via an alpha-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C(sp(3))-N bond, wherein O-2 served as a green oxidant. This protocol provided a domino method for the synthesis of Spiro [cyclohexane-1,12'-isoindolo[1,2-b]quinazolin]-10'-ones containing a nitrogen-substituted quaternary carbon center.

引用

收藏

页码：2887 / 2891

页数：5

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