The Roles of Thrombospondins in Hemorrhagic Stroke

被引：13

作者：

Wu, Xuan ^{[1
]}

Luo, Xu ^{[1
]}

Zhu, Qiquan ^{[1
]}

Zhang, Jie ^{[1
]}

Liu, Yun ^{[1
]}

Luo, Hansheng ^{[1
]}

Cheng, Yuan ^{[1
]}

Xie, Zongyi ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing 400010, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

INCREASED VASCULAR DENSITY; INTRACEREBRAL HEMORRHAGE; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MESSENGER-RNA; EXPRESSION; ANGIOGENESIS; ACTIVATION; PEPTIDE; PROTEIN;

D O I：

10.1155/2017/8403184

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hemorrhagic stroke is a devastating cerebrovascular disease with significant morbidity and mortality worldwide. Thrombospondins (TSPs), as matricellular proteins, belong to the TSP family which is comprised of five members. All TSPs modulate a variety of cellular functions by binding to various receptors. Recently, TSPs gained attention in the area of hemorrhagic stroke, especially TSP-1. TSP-1 participates in angiogenesis, the inflammatory response, apoptosis, and fibrosis after hemorrhagic stroke through binding to various molecules including but not limited to CD36, CD47, and TGF-beta. In this review, we will discuss the roles of TSPs in hemorrhagic stroke and focus primarily on TSP-1.

引用

页数：8

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