Aging-related alterations in the expression and distribution of GluR2 and PICK1 in the rat hippocampus

被引：15

作者：

Yu, Dan-Fang ^{[1
]}

Wu, Peng-Fei ^{[1
]}

Fu, Hui ^{[1
,2
,3
]}

Cheng, Jin ^{[1
]}

Yang, Yuan-Jian ^{[1
]}

Chen, Tao ^{[1
]}

Long, Li-Hong ^{[1
,2
,3
]}

Chen, Jian-Guo ^{[1
,2
,3
]}

Wang, Fang ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pharmacol, Wuhan 430030, Hubei, Peoples R China

[2] Minist Educ China, Key Lab Neurol Dis HUST, Wuhan 430030, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Inst Biomed & Drug Discovery, Wuhan 430030, Hubei, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2011年 / 497卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Aging; GluR2; PICK1; PKC alpha; Calcineurin; DOMAIN-CONTAINING PROTEINS; AMPA RECEPTOR SUBUNITS; NMDA RECEPTOR; BINDING-PROTEIN; DIFFERENTIAL PALMITOYLATION; SYNAPTIC PLASTICITY; SURFACE EXPRESSION; CALCINEURIN; AGE; CELLS;

D O I：

10.1016/j.neulet.2011.04.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deficit in synaptic plasticity in the hippocampus frequently occurs during normal aging. Although the protein level and calcium permeability of AMPARs alter with aging, the alteration of AMPARs and their regulatory proteins during aging are far from understanding. Dynamics of GluR2 subunit are dependent on the function of protein interacting with C alpha kinase 1 (PICK1), PKC alpha and calcineurin (CaN). Here, we firstly show that the expression of PICK1 and CaN B decreased significantly in the hippocampus of old rats compared to that of young and adult rats. The decrease was accompanied by a reduction of GluR2 and PKC alpha and an increase in CaN A. Next, we found that in young and adult rats, the distribution of PICK1 and GluR2 diffused in the cytoplasm of hippocampal neurons, but closely around perinuclear in the hippocampal neurons of old rats. These results suggest that the expression of GluR2, PICK1, PKC alpha and CaN B significant decreased in the hippocampus and these alterations may lead to altered distribution of GluR2 and PICK1 during aging. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：42 / 45

页数：4

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