Genetic Regulation of Pre-Pubertal Development of Body Mass Index: A Longitudinal Study of Japanese Twin Boys and Girls

被引：12

作者：

Silventoinen, Karri ^{[1
,2
]}

Kaprio, Jaakko ^{[1
,3
,4
]}

Yokoyama, Yoshie ^{[5
]}

机构：

[1] Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Populat Res Unit, Dept Social Res, FIN-00014 Helsinki, Finland

[3] Natl Inst Hlth & Welf, Dept Mental Hlth, Helsinki, Finland

[4] Inst Mol Med FIMM, Helsinki, Finland

[5] Osaka City Univ, Dept Community Hlth Nursing, Osaka 558, Japan

来源：

BEHAVIOR GENETICS | 2011年 / 41卷 / 02期

关键词：

BMI; Children; Genetics; Twins; Asian populations; NATIONAL NUTRITION SURVEY; ENVIRONMENTAL-INFLUENCES; BIRTH-WEIGHT; CHILDHOOD OVERWEIGHT; ADOLESCENT TWINS; SEX-DIFFERENCES; YOUNG TWINS; 8; COUNTRIES; OBESITY; HEIGHT;

D O I：

10.1007/s10519-010-9380-y

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We analyzed the genetic architecture of prepubertal development of relative weight to height in 216 monozygotic and 159 dizygotic complete Japanese twin pairs (52% girls). Ponderal index at birth (kg/m(3)) and body mass index (BMI, kg/m(2)) from 1 to 11 years of age were used. Additive genetic factors explained the major proportion (52-74%) of the variation of BMI from 1 to 11 years of age. Environmental factors common to both co-twins also showed some effect (7-28%), but at most ages this was not statistically significant. Strong genetic tracking was found for BMI from 1 to 11 years of age, but there was also evidence for a persistent effect of common environmental factors. Our results suggest that the genetic architecture of BMI development in the Japanese population is generally similar to that found in previous twin studies in Caucasian populations.

引用

页码：234 / 241

页数：8

共 34 条

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