Highly Efficient InBr3 Catalyzed Michael Addition of Indoles to α,β-Unsaturated Esters

被引：5

作者：

Liu Ping ^{[1
]}

Chen Wei ^{[1
]}

Ren Kai ^{[1
]}

Wang Lei ^{[1
,2
]}

机构：

[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Michael addition; indole; alpha; beta-unsaturated ester; Lewis acid; InBr3; CONJUGATE ADDITION; INDIUM TRIBROMIDE; WATER; ACID; ALKALOIDS; TRIFLUOROMETHANESULFONATES; HAPALINDOLES; ALKYLATION; KETONES; ENONES;

D O I：

10.1002/cjoc.201190011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient synthetic strategy toward Michael addition of indoles to alpha,beta-unsaturated esters has been developed using Lewis acid InBr3 as catalyst. The reactions generated 3-substituted indoles in high yields with excellent regio-selectivity in the presence of catalytic amount of InBr3 under mild reaction conditions. The method is simple, efficient and practical.

引用

页码：2399 / 2403

页数：5

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