Highly Efficient InBr3 Catalyzed Michael Addition of Indoles to α,β-Unsaturated Esters

被引：5
|
作者：
Liu Ping [1 ]
Chen Wei [1 ]
Ren Kai [1 ]
Wang Lei [1 ,2 ]
机构：
[1] Huaibei Normal Univ, Dept Chem, Huaibei 235000, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Michael addition; indole; alpha; beta-unsaturated ester; Lewis acid; InBr3; CONJUGATE ADDITION; INDIUM TRIBROMIDE; WATER; ACID; ALKALOIDS; TRIFLUOROMETHANESULFONATES; HAPALINDOLES; ALKYLATION; KETONES; ENONES;
D O I：
10.1002/cjoc.201190011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient synthetic strategy toward Michael addition of indoles to alpha,beta-unsaturated esters has been developed using Lewis acid InBr3 as catalyst. The reactions generated 3-substituted indoles in high yields with excellent regio-selectivity in the presence of catalytic amount of InBr3 under mild reaction conditions. The method is simple, efficient and practical.
引用
收藏
页码：2399 / 2403
页数：5
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