Inflammation and depression in young people: a systematic review and proposed inflammatory pathways

被引：55
作者：
Toenders, Yara J. [1 ,2 ]
Laskaris, Liliana [1 ,2 ]
Davey, Christopher G. [3 ]
Berk, Michael [1 ,2 ,3 ,4 ,5 ]
Milaneschi, Yuri [6 ,7 ]
Lamers, Femke [6 ,7 ]
Penninx, Brenda W. J. H. [6 ,7 ]
Schmaal, Lianne [1 ,2 ]
机构：
[1] Orygen, Parkville, Vic, Australia
[2] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia
[3] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
[4] Deakin Univ, Sch Med, Barwon Hlth, IMPACT Inst Mental & Phys Hlth & Clin Translat, Geelong, Vic, Australia
[5] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia
[6] Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Dept Amsterdam Publ Hlth,Res Inst, Amsterdam, Netherlands
[7] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam, Netherlands
来源：
MOLECULAR PSYCHIATRY | 2022年 / 27卷 / 01期
基金：
澳大利亚国家健康与医学研究理事会; 英国惠康基金;
关键词：
C-REACTIVE PROTEIN; COGNITIVE-BEHAVIORAL THERAPY; POPULATION-BASED SAMPLE; LIFE-STYLE FACTORS; CYTOKINE LEVELS; MENTAL-HEALTH; PROINFLAMMATORY MARKERS; ADOLESCENT DEPRESSION; MAJOR DEPRESSION; IMMUNE-SYSTEM;
D O I：
10.1038/s41380-021-01306-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.
引用
收藏
页码：315 / 327
页数：13
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