Candida-Epithelial Interactions

被引：61

作者：

Richardson, Jonathan P. ^{[1
]}

Ho, Jemima ^{[1
]}

Naglik, Julian R. ^{[1
]}

机构：

[1] Kings Coll London, Dent Inst, Mucosal & Salivary Biol Div, London SE1 1UL, England

来源：

JOURNAL OF FUNGI | 2018年 / 4卷 / 01期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

epithelial cell; Candida; fungus; mucosal infection; commensalism; pathogenicity; microbiota; CELL-SURFACE HYDROPHOBICITY; SECRETED ASPARTYL PROTEINASES; TRANSGLUTAMINASE SUBSTRATE; ALBICANS INFECTION; BIOFILM FORMATION; IN-VITRO; PARAPSILOSIS; ADHESIN; VIRULENCE; ADHERENCE;

D O I：

10.3390/jof4010022

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A plethora of intricate and dynamic molecular interactions occur between microbes and the epithelial cells that form the mucosal surfaces of the human body. Fungi, particularly species of Candida, are commensal members of our microbiota, continuously interacting with epithelial cells. Transient and localised perturbations to the mucosal environment can facilitate the overgrowth of fungi, causing infection. This minireview will examine the direct and indirect mechanisms by which Candida species and epithelial cells interact with each other, and explore the factors involved in the central processes of adhesion, invasion, and destruction of host mucosal surfaces.

引用

页数：14

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