Orbito-Frontal Cortex Hypometabolism in Children With Post-COVID Condition (Long COVID): A Preliminary Experience

被引：25
作者：
Cocciolillo, Fabrizio [1 ]
Di Giuda, Daniela [1 ,2 ]
Morello, Rosa [3 ]
De Rose, Cristina [3 ]
Valentini, Piero [3 ]
Buonsenso, Danilo [3 ,4 ]
机构：
[1] Fdn Policlin Univ Agostino Gemelli IRCCS, UOC Med Nucl, Dipartimento Diagnost Immagini Radioterapia Oncol, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Ist Med Nucl, Rome, Italy
[3] Fdn Policlin Univ A Gemelli IRC, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy
[4] Univ Cattolica Sacro Cuore, Ist Igiene, Global Hlth Res Inst, Rome, Italy
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2022年 / 41卷 / 08期
关键词：
long covid; children; brain; PET; orbito-frontal cortex; SEQUELAE;
D O I：
10.1097/INF.0000000000003578
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We describe 3 children with new-onset neurocognitive problems after coronavirus disease 2019 (COVID-19), that showed, at the brain [18F]-fluorodeoxyglucose positron emission tomography/computed tomography, hypometabolism in the left orbito-frontal region. The voxel-wise analysis confirmed a cluster of hypometabolic voxels in this region with a peak at -18/46/-4mm (179 voxels, T-Score 8.1). These findings may explain neurocognitive symptoms that some children develop after COVID-19 and require further investigations
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收藏
页码：663 / 665
页数：3
相关论文
共 12 条
[1]   Clinical characteristics, activity levels and mental health problems in children with long coronavirus disease: a survey of 510 children [J].
Buonsenso, Danilo ;
Pujol, Ferran Espuny ;
Munblit, Daniel ;
Pata, Davide ;
McFarland, Sammie ;
Simpson, Frances K. .
FUTURE MICROBIOLOGY, 2022, 17 (08) :577-588
[2]   Evidence of lung perfusion defects and ongoing inflammation in an adolescent with post-acute sequelae of SARS-CoV-2 infection [J].
Buonsenso, Danilo ;
Di Giuda, Daniela ;
Sigfrid, Louise ;
Pizzuto, Daniele Antonio ;
Di Sante, Gabriele ;
De Rose, Cristina ;
Lazzareschi, Ilaria ;
Sali, Michela ;
Baldi, Fabiana ;
Chieffo, Daniela Pia Rosaria ;
Munblit, Daniel ;
Valentini, Piero .
LANCET CHILD & ADOLESCENT HEALTH, 2021, 5 (09) :677-680
[3]  
Douaud G, 2022, NATURE, V604, P697, DOI [10.1038/s41586-022-04569-5, 10.1101/2021.06.11.21258690]
[4]   18FDG PET/CT Scan Reveals Hypoactive Orbitofrontal Cortex in Anosmia of COVID-19 [J].
Karimi-Galougahi, Mahboobeh ;
Yousefi-Koma, Abbas ;
Bakhshayeshkaram, Mehrdad ;
Raad, Nasim ;
Haseli, Sara .
ACADEMIC RADIOLOGY, 2020, 27 (07) :1042-1043
[5]   The cerebral network of COVID-19-related encephalopathy: a longitudinal voxel-based 18F-FDG-PET study [J].
Kas, Aurelie ;
Soret, Marine ;
Pyatigoskaya, Nadya ;
Habert, Marie-Odile ;
Hesters, Adele ;
Le Guennec, Loic ;
Paccoud, Olivier ;
Bombois, Stephanie ;
Delorme, Cecile .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (08) :2543-2557
[6]   Pathological sequelae of long-haul COVID [J].
Mehandru, Saurabh ;
Merad, Miriam .
NATURE IMMUNOLOGY, 2022, 23 (02) :194-202
[7]   Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review [J].
Meyer, Philipp T. ;
Hellwig, Sabine ;
Blazhenets, Ganna ;
Hosp, Jonas A. .
JOURNAL OF NUCLEAR MEDICINE, 2022, 63 (07) :971-980
[8]   Similar patterns of [18F]-FDG brain PET hypometabolism in paediatric and adult patients with long COVID: a paediatric case series [J].
Morand, Aurelie ;
Campion, Jacques-Yves ;
Lepine, Anne ;
Bosdure, Emmanuelle ;
Luciani, Lea ;
Cammilleri, Serge ;
Chabrol, Brigitte ;
Guedj, Eric .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (03) :913-920
[9]   Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study [J].
Osmanov, Ismail M. ;
Spiridonova, Ekaterina ;
Bobkova, Polina ;
Gamirova, Aysylu ;
Shikhaleva, Anastasia ;
Andreeva, Margarita ;
Blyuss, Oleg ;
El-Taravi, Yasmin ;
DunnGalvin, Audrey ;
Comberiati, Pasquale ;
Peroni, Diego G. ;
Apfelbacher, Christian ;
Genuneit, Jon ;
Mazankova, Lyudmila ;
Miroshina, Alexandra ;
Chistyakova, Evgeniya ;
Samitova, Elmira ;
Borzakova, Svetlana ;
Bondarenko, Elena ;
Korsunskiy, Anatoliy A. ;
Konova, Irina ;
Hanson, Sarah Wulf ;
Carson, Gail ;
Sigfrid, Louise ;
Scott, Janet T. ;
Greenhawt, Matthew ;
Whittaker, Elizabeth A. ;
Garralda, Elena ;
Swann, Olivia, V ;
Buonsenso, Danilo ;
Nicholls, Dasha E. ;
Simpson, Frances ;
Jones, Christina ;
Semple, Malcolm G. ;
Warner, John O. ;
Vos, Theo ;
Olliaro, Piero ;
Munblit, Daniel .
EUROPEAN RESPIRATORY JOURNAL, 2022, 59 (02)
[10]   The functions of the orbitofrontal cortex [J].
Rolls, ET .
BRAIN AND COGNITION, 2004, 55 (01) :11-29
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