Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review

被引：10

作者：

Lopez-Santillan, Maria ^{[1
,2
]}

Lopez-Lopez, Elixabet ^{[1
,3
]}

Alvarez-Gonzalez, Paula ^{[1
]}

Martinez, Garazi ^{[1
]}

Arzuaga-Mendez, Javier ^{[1
,4
]}

Ruiz-Diaz, Irune ^{[5
]}

Guerra-Merino, Isabel ^{[6
]}

Gutierrez-Camino, Angela ^{[1
,3
,7
]}

Martin-Guerrero, Idoia ^{[3
,8
]}

机构：

[1] Univ Basque Country, Fac Med & Nursing, Dept Genet Phys Anthropol & Anim Physiol, UPV EHU, Barrio Sarriena S N, Leioa 48940, Spain

[2] Basurto Univ Hosp, Med Oncol Serv, Ave Montevideo 18, Bilbao 48013, Spain

[3] Biocruces Bizkaia Hlth Res Inst, Pediat Oncol Grp, Plaza Cruces S N, Baracaldo 48903, Spain

[4] Biocruces Bizkaia Hlth Res Inst, Hematol Neoplasm Grp, Plaza Cruces S-N, Baracaldo, Spain

[5] Donostia Univ Hosp, Pathol Dept, Paseo Doctor Begiristain 109, San Sebastian 20014, Spain

[6] Araba Univ Hosp, Pathol Dept, Calle Jose Atxotegi S-N, Vitoria 01009, Spain

[7] CHU Sainte Justine Res Ctr, Div Hematol Oncol, 3175 Chemin Cote Sainte Catherine, Montreal, PQ H3T 1C5, Canada

[8] Univ Basque Country, Fac Sci & Technol, Dept Genet Phys Anthropol & Anim Physiol, UPV EHU, Barrio Sarriena S-N, Leioa 48940, Spain

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 165卷

关键词：

Diffuse large B-cell lymphoma; Somatic mutation; Outcome; Therapeutic target; P53; GENE-MUTATIONS; POOR SURVIVAL; TUMOR-SUPPRESSOR; RITUXIMAB-CHOP; TP53; PREDICT; EZH2; CLASSIFICATION; METHYLATION; DISRUPTION;

D O I：

10.1016/j.critrevonc.2021.103430

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL), the most common type of Non-Hodgkin lymphoma (NHL), is a highly heterogeneous and aggressive disease. Regardless of this heterogeneity, all patients receive the same first-line therapy, which fails in 30-40 % of patients, who are either refractory or relapse after remission. With the aim of stratifying patients to improve treatment outcome, different clinical and genetic biomarkers have been studied. The present systematic review aimed to identify somatic mutations that could serve as prognosis biomarkers or as therapeutic target mutations in DLBCL. Regarding their role as prognostic markers, mutations in CD58 and TP53 seem the most promising predictors of poor outcome although the combination of different alterations and other prognostic factors could be a more powerful strategy. On the other hand, different approaches regarding targeted therapy have been proposed. Therefore, mutational analysis could help guide treatment choice in DLBCL yet further studies and clinical trials are needed.

引用

页数：11

共 65 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Non-Hodgkin lymphoma [J].

Armitage, James O. ;

Gascoyne, Randy D. ;

Lunning, Matthew A. ;

Cavalli, Franco .

LANCET, 2017, 390 (10091) :298-310

[3] Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma [J].

Arthur, Sarah E. ;

Jiang, Aixiang ;

Grande, Bruno M. ;

Alcaide, Miguel ;

Cojocaru, Razvan ;

Rushton, Christopher K. ;

Mottok, Anja ;

Hilton, Laura K. ;

Lat, Prince Kumar ;

Zhao, Eric Y. ;

Culibrk, Luka ;

Ennishi, Daisuke ;

Jessa, Selin ;

Chong, Lauren ;

Thomas, Nicole ;

Pararajalingam, Prasath ;

Meissner, Barbara ;

Boyle, Merrill ;

Davidson, Jordan ;

Bushell, Kevin R. ;

Lai, Daniel ;

Farinha, Pedro ;

Slack, Graham W. ;

Morin, Gregg B. ;

Shah, Sohrab ;

Sen, Dipankar ;

Jones, Steven J. M. ;

Mungall, Andrew J. ;

Gascoyne, Randy D. ;

Audas, Timothy E. ;

Unrau, Peter ;

Marra, Marco A. ;

Connors, Joseph M. ;

Steidl, Christian ;

Scott, David W. ;

Morin, Ryan D. .

NATURE COMMUNICATIONS, 2018, 9

[4] Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another "double hit" lymphoma with very poor outcome? [J].

Asmar, Fazila ;

Hother, Christoffer ;

Kulosman, Gorjan ;

Treppendahl, Marianne Bach ;

Nielsen, Helene Myrtue ;

Ralfkiaer, Ulrik ;

Pedersen, Anja ;

Moller, Michael Boe ;

Ralfkiaer, Elisabeth ;

Brown, Peter de Nully ;

Gronbaek, Kirsten .

ONCOTARGET, 2014, 5 (07) :1912-1925

[5] HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes [J].

Bekker-Jensen, Simon ;

Danielsen, Jannie Rendtlew ;

Fugger, Kasper ;

Gromova, Irina ;

Nerstedt, Annika ;

Bartek, Jiri ;

Lukas, Jiri ;

Mailand, Niels .

NATURE CELL BIOLOGY, 2010, 12 (01) :80-U209

[6] The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma [J].

Bertrand, P. ;

Maingonnat, C. ;

Penther, D. ;

Guney, S. ;

Ruminy, P. ;

Picquenot, J. M. ;

Mareschal, S. ;

Alcantara, M. ;

Bouzelfen, A. ;

Dubois, S. ;

Figeac, M. ;

Bastard, C. ;

Tilly, H. ;

Jardin, F. .

GENES CHROMOSOMES & CANCER, 2013, 52 (08) :764-774

[7] Prognostic impact of somatic mutations in diffuse large B-cell lymphoma and relationship to cell-of-origin: data from the phase III GOYA study [J].

Bolen, Christopher R. ;

Klanova, Magdalena ;

Trneny, Marek ;

Sehn, Laurie H. ;

He, Jie ;

Tong, Jing ;

Paulson, Joseph N. ;

Kim, Eugene ;

Vitolo, Umberto ;

Rocco, Alice Di ;

Fingerle-Rowson, Guenter ;

Nielsen, Tina ;

Lenz, Georg ;

Oestergaard, Mikkel Z. .

HAEMATOLOGICA, 2020, 105 (09) :2298-2307

[8] Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer [J].

Bonanno, Laura ;

Costa, Carlota ;

Majem, Margarita ;

Sanchez, Jose-Javier ;

Rodriguez, Ignacio ;

Gimenez-Capitan, Ana ;

Angel Molina-Vila, Miquel ;

Vergnenegre, Alain ;

Massuti, Bartomeu ;

Favaretto, Adolfo ;

Rugge, Massimo ;

Pallares, Cinta ;

Taron, Miquel ;

Rosell, Rafael .

BMC CANCER, 2016, 16

[9] Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma [J].

Bu, Rong ;

Bavi, Prashant ;

Abubaker, Jehad ;

Jehan, Zeenath ;

Al-Haqawi, Wael ;

Ajarim, Dahish ;

Al-Dayel, Fouad ;

Uddin, Shahab ;

Al-Kuraya, Khawla S. .

LEUKEMIA & LYMPHOMA, 2012, 53 (10) :1971-1977

[10] TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics [J].

Campo, Elias ;

Cymbalista, Florence ;

Ghia, Paolo ;

Jaeger, Ulrich ;

Pospisilova, Sarka ;

Rosenquist, Richard ;

Schuh, Anna ;

Stilgenbauer, Stephan .

HAEMATOLOGICA, 2018, 103 (12) :1956-1968

← 1 2 3 4 5 6 7 →