Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex

被引：60

作者：

Lee, Jasinda H. ^{[1
,2
]}

Agacinski, Grzegorz ^{[3
]}

Williams, Jonathan H. ^{[3
]}

Wilcock, Gordon K. ^{[3
]}

Esiri, Margaret M. ^{[3
]}

Francis, Paul T. ^{[4
]}

Wong, Peter T-H ^{[1
,2
]}

Chen, Christopher P. ^{[1
,2
]}

Lai, Mitchell K. ^{[1
,2
,5
]}

机构：

[1] Natl Univ Singapore, Dept Pharmacol, Yong Loo Lin Sch Med, MACC, Singapore 117597, Singapore

[2] Natl Univ Hlth Syst, Memory Aging & Cognit Ctr, Singapore, Singapore

[3] Univ Oxford, Oxford Project Investigate Memory & Ageing OPTIMA, Oxford, England

[4] Kings Coll London, Wolfson Ctr Age Related Dis, London WC2R 2LS, England

[5] Singapore Gen Hosp, Dept Clin Res, Singapore 0316, Singapore

来源：

NEUROCHEMISTRY INTERNATIONAL | 2010年 / 57卷 / 08期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; Dementia; Cannabinoid CB1 receptors; Cortex; Hippocampus; Caudate; HUMAN BRAIN; ENDOGENOUS CANNABINOIDS; DEMENTIA; DIAGNOSIS; BINDING; PREVALENCE; EXPRESSION; MARIJUANA; COMPONENT; SUBTYPES;

D O I：

10.1016/j.neuint.2010.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cannabinoid CB1 receptor has gained much attention a, a potential pharmacotherapeutic target in various neurodegenerative diseases including Alzheimer's disease (AD) However the relation of CB1 receptors to cognitive function in AD is at present unclear in this study postmortem brain tissues from a cohort of prospectively assessed neuropathologically confirmed AD patients and aged controls were used to measure CBI receptors by immunoblotting and a ubset of subjects also had [H-3]SR141716A binding Correlational analyses were then performed for the neurochemical and cognitive data We found that CBI receptor levels in were unchanged AD in the brain regions assessed (frontal cortex anterior cingulate gyrus hippocampus caudate nucleus) Within the AD group frontal cortical CM immunoreactivity correlated with cognitive scores assessed within a year of death Our study suggests that CBI receptors are intact in AD and may play a role in preserving cognitive function Therefore CB1 receptors should be further assessed as a potential therapeutic target in AD (C) 2010 Elsevier Ltd All rights reserved

引用

页码：985 / 989

页数：5

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