Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

被引:173
|
作者
Zhu, Quangang [1 ]
Chen, Zhongjian [1 ]
Paul, Pijush Kumar [1 ,3 ]
Lu, Yi [1 ,2 ]
Wu, Wei [1 ,2 ]
Qi, Jianping [1 ,2 ]
机构
[1] Tongji Univ, Shanghai Skin Dis Hosp, Sch Med, Shanghai 200443, Peoples R China
[2] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery MOE, Shanghai 201203, Peoples R China
[3] Gono Bishwabidyalay Univ, Dept Pharm, Dhaka 1344, Bangladesh
基金
中国国家自然科学基金;
关键词
Proteins; Peptides; Oral delivery; Permeation enhancer; Enzyme inhibitor; Stability; Clinical; SOLID LIPID NANOPARTICLES; TRIMETHYL CHITOSAN NANOPARTICLES; MUCUS-PENETRATING NANOPARTICLES; IMPRINTED POLYMER NANOPARTICLES; CALCIUM-PHOSPHATE NANOPARTICLES; GASTROINTESTINAL PH PROFILES; EPITHELIAL TIGHT JUNCTIONS; LIPOSOME-ENTRAPPED INSULIN; CAPPED GOLD NANOPARTICLES; CELL-HOMING PEPTIDE;
D O I
10.1016/j.apsb.2021.04.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route. Given the big demand for oral administration in clinical use, a variety of researches focused on developing new technologies to overcome GI barriers of PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, as well as intestinal microdevices. Some new technologies have been developed under clinical trials and even on the market. This review summarizes the history, the physiological barriers and the overcoming approaches, current clinical and preclinical technologies, and future prospects of oral delivery of PPs. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
引用
收藏
页码:2416 / 2448
页数:33
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