Is SELDI-TOF a valid tool for diagnostic biomarkers?

被引：16
作者：
Ndao, Momar [1 ,3 ]
Rainczuk, Adam [1 ]
Rioux, Marie-Claire [2 ]
Spithill, Terry W. [2 ,3 ,4 ]
Ward, Brian J. [1 ,3 ]
机构：
[1] McGill Univ, Natl Reference Ctr Farasitol, Res Inst, Ctr Hlth,Montreal Gen Hosp R3 137, Montreal, PQ H3G 1A4, Canada
[2] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X 3V9, Canada
[3] McGill Univ, FQRNT Ctr Host Parasite Interact, Montreal, PQ H3G 1A4, Canada
[4] Charles Stuart Univ, Sch Anim & Vet Sci, Wagga Wagga, NSW 2678, Australia
来源：
TRENDS IN PARASITOLOGY | 2010年 / 26卷 / 12期
基金：
加拿大健康研究院;
关键词：
LASER-DESORPTION/IONIZATION-TIME; FLIGHT MASS-SPECTROMETRY; CHRONIC HEPATITIS-C; TRYPANOSOMA-CRUZI; CHAGAS-DISEASE; SERUM BIOMARKERS; ASYMPTOMATIC CARRIERS; PROTEIN-PATTERNS; BREAST-CANCER; BLOOD-DONORS;
D O I：
10.1016/j.pt.2010.07.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The genome revolution is providing fresh insights into host and parasite genomes, and new tools are becoming available for examining host-parasite interactions at the proteome level. Technologies such as surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS) can be applied to discover biomarkers (alterations in both host and parasite proteomes) associated with parasitic diseases. Such biomarkers can represent host proteins, fragments of host proteins or parasite proteins that appear in body fluids or tissues following infection. Individual biomarkers or biomarker patterns. not only have diagnostic utility (e.g. in active disease, prognosis, tests of cure) but can also provide unique insights into the mechanisms underlying host responses and pathogenesis.
引用
收藏
页码：561 / 567
页数：7
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