3D-printed poly-ε-caprolactone-CaCO3-biocomposite-scaffolds for hard tissue regeneration

被引：17
|
作者：
Neumann, R. [1 ]
Neunzehn, J. [1 ]
Hinueber, C. [2 ]
Flath, T. [3 ]
Schulze, F. P. [3 ]
Wiesmann, H-P [1 ]
机构：
[1] Tech Univ Dresden, Inst Mat Sci, Dept Biomat, Budapester Str 27, D-01069 Dresden, Germany
[2] Leibniz Inst Polymer Res Dresden, Dept Proc, Hohe Str 6, D-01069 Dresden, Germany
[3] Univ Appl Sci Leipzig, Dept Mech & Energy Engn, Karl Liebknecht Str 134, D-04277 Leipzig, Germany
来源：
EXPRESS POLYMER LETTERS | 2019年 / 13卷 / 01期
关键词：
biocomposites; mechanical properties; biodegradable polymers; 3D-printing; tissue engineering; CROSS-LINKED POLY(EPSILON-CAPROLACTONE); EPSILON-CAPROLACTONE; COMPOSITE SCAFFOLDS; POLYCAPROLACTONE SCAFFOLDS; ENGINEERING APPLICATIONS; HYDROLYTIC DEGRADATION; RHEOLOGICAL PROPERTIES; POLY(ETHYLENE GLYCOL); MECHANICAL-PROPERTIES; RESIN COMPOSITES;
D O I：
10.3144/expresspolymlett.2019.2
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Adopting the beneficial chemical composition of mineral bone grafts and the interesting biomedical properties of the approved polycaprolactone, versatile manufacturing processes offering a near-net-shape fabrication and cost-effective scalability, has been used to fabricate highly porous polymer-ceramic biocomposite scaffolds with different amounts of the inorganic component CaCO3 by molded casting and fused deposition modelling. The mechanical properties and surface characteristics were evaluated after several steps of degradation by means of compression tests and scanning electron microscopy, respectively. Calcium release has been determined over a period of 4 weeks and the calcium phosphate phase formation on the surface was observed and validated by energy dispersive x-ray spectroscopy. The established production path and the use of the material combination polycaprolactone and calcium carbonate has enormous potential to manufacture individual and application-oriented open-porous scaffolds for hard tissue replacement.
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页码：2 / 17
页数：16
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