Pyridazine and phthalazine derivatives with potential antimicrobial activity

被引：62

作者：

Butnariu, Roxana M.

Caprosu, Maria D.

Bejan, Vasilichia

Ungureanu, Margareta

Poiata, Antonia

Tuchilus, Cristina

Florescu, Margareta

Mangalagiu, Ionel I.

机构：

[1] Alexandru Ioan Cuza Univ, Organ Biochem Dept, R-70050 Iasi, Romania

[2] Univ Med & Pharm Gr T Popa Iasi, R-700115 Iasi, Romania

[3] Acad Econ Sci, R-01374 Bucharest, Romania

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 05期

关键词：

D O I：

10.1002/jhet.5570440528

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fifteen new pyridazine and phthalazine derivatives were prepared (in good to excellent yields) and tested in vitro as antimicrobial compounds. All the compounds have proved to have a remarkable activity against Gram positive germs, the results on Sarciria Luteea being spectacular. Correlation structure biological activity have been done. Stereo- and region- chemistry involved in these reactions are discussed.

引用

页码：1149 / 1152

页数：4

共 15 条

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