Pyridazine and phthalazine derivatives with potential antimicrobial activity

被引:62
作者
Butnariu, Roxana M.
Caprosu, Maria D.
Bejan, Vasilichia
Ungureanu, Margareta
Poiata, Antonia
Tuchilus, Cristina
Florescu, Margareta
Mangalagiu, Ionel I.
机构
[1] Alexandru Ioan Cuza Univ, Organ Biochem Dept, R-70050 Iasi, Romania
[2] Univ Med & Pharm Gr T Popa Iasi, R-700115 Iasi, Romania
[3] Acad Econ Sci, R-01374 Bucharest, Romania
关键词
D O I
10.1002/jhet.5570440528
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Fifteen new pyridazine and phthalazine derivatives were prepared (in good to excellent yields) and tested in vitro as antimicrobial compounds. All the compounds have proved to have a remarkable activity against Gram positive germs, the results on Sarciria Luteea being spectacular. Correlation structure biological activity have been done. Stereo- and region- chemistry involved in these reactions are discussed.
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收藏
页码:1149 / 1152
页数:4
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