Dendritic-cell immunotherapy:: from ex vivo loading to in vivo targeting

被引：618
作者：
Tacken, Paul J. [1 ]
de Vries, I. Jolanda M. [1 ]
Torensma, Ruurd [1 ]
Figdor, Carl G. [1 ]
机构：
[1] Radboud Univ Nijmegen, Nijmegen Ctr Mol Life Sci, Med Ctr, NL-6500 HB Nijmegen, Netherlands
来源：
NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 10期
关键词：
D O I：
10.1038/nri2173
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The realization that dendritic cells (DCs) orchestrate innate and adaptive immune responses has stimulated research on harnessing DCs to create more effective vaccines. Early clinical trials exploring autologous DCs that were loaded with antigens ex vivo to induce T-cell responses have provided proof of principle. Here, we discuss how direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large - scale application of DC-based vaccination therapies.
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页码：790 / 802
页数：13
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