Cassette in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of Epoxides

被引：37
作者：
Dey, Sangeeta
Powell, Douglas R.
Hu, Chunhua
Berkowitz, David B. [1 ]
机构：
[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
[2] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 37期
关键词：
asymmetric catalysis; cobalt; combinatorial chemistry; enantioselectivity; UV/Vis spectroscopy;
D O I：
10.1002/anie.200701280
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：7010 / 7014
页数：5
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