Mesenchymal Stromal Cells Perspective: New Potential Therapeutic for the Treatment of Neurological Diseases

被引：9
作者：
Mukai, Takeo [1 ,2 ]
Sei, Kenshi [2 ]
Nagamura-Inoue, Tokiko [2 ]
机构：
[1] Univ Tokyo Hosp, Dept Pediat, Bunkyo Ku, Tokyo 1138655, Japan
[2] Univ Tokyo, Inst Med Sci, Dept Cell Proc & Transfus, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan
来源：
PHARMACEUTICS | 2021年 / 13卷 / 08期
基金：
日本学术振兴会;
关键词：
mesenchymal stromal cell; umbilical cord; neurological disorders; cerebral palsy; neurotrophic factor; AMYOTROPHIC-LATERAL-SCLEROSIS; PROGRESSIVE MULTIPLE-SCLEROSIS; SPINAL-CORD-INJURY; PHASE-I TRIAL; STEM-CELLS; UMBILICAL-CORD; EXTRACELLULAR VESICLES; MOUSE MODEL; INTERNATIONAL-SOCIETY; PARKINSONS-DISEASE;
D O I：
10.3390/pharmaceutics13081159
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several studies have shown that mesenchymal stromal/stem cells (MSCs) exert their neuroprotective and neurorestorative efficacy via the secretion of neurotrophic factors. Based on these studies, many clinical trials using MSCs for the treatment of neurological disorders have been conducted, and results regarding their feasibility and efficacy have been reported. The present review aims to highlight the characteristics and basic research regarding the role of MSCs in neurological disease and to discuss the recent progress in clinical trials using MSCs to treat various neurological disorders.
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页数：17
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