The Potential Use of Resveratrol for Cancer Prevention

被引:99
作者
Vervandier-Fasseur, Dominique [1 ]
Latruffe, Norbert [2 ]
机构
[1] Univ Bourgogne Franche Comte, Univ Burgundy, Inst Mol Chem, Team OCS,ICMUB,CNRS,UMR 6302, F-21000 Dijon, France
[2] Univ Bourgogne Franche Comte, Team BioPeroxIL, Biochem Peroxisome Inflammat & Lipid Metab EA7270, INSERM, F-21000 Dijon, France
来源
MOLECULES | 2019年 / 24卷 / 24期
关键词
cancer; prevention; resveratrol; approach strategies; mechanisms; innovative formulations; CELL-CYCLE PROGRESSION; CHEMOPREVENTIVE AGENT; TRANS-RESVERATROL; RED WINE; APOPTOSIS; QUERCETIN; PROLIFERATION; RAFTS; BIOAVAILABILITY; REDISTRIBUTION;
D O I
10.3390/molecules24244506
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In addition to the traditional treatments of cancer and cancer prevention, the use of natural compounds, especially those found in food, should be considered. To clarify if resveratrol has the potential for cancer prevention and the possibility of use in therapy, the following must be taken into account: data from epidemiology, clinical protocol (case and control), preclinical studies (lab animals), use of established cell lines as models of cancer cells, test tube assays (enzymes activities), and requirements of nanotechnologies in order to discover new drugs to fight cancer. From this perspective and future expected advances, more information is needed such as improved efficacy, methods of application, and the synergistic sensitization of resveratrol as an adjuvant. In addition, resveratrol nanoformulation is considered to overcome its weak bioavailability.
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页数:12
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