In addition to the traditional treatments of cancer and cancer prevention, the use of natural compounds, especially those found in food, should be considered. To clarify if resveratrol has the potential for cancer prevention and the possibility of use in therapy, the following must be taken into account: data from epidemiology, clinical protocol (case and control), preclinical studies (lab animals), use of established cell lines as models of cancer cells, test tube assays (enzymes activities), and requirements of nanotechnologies in order to discover new drugs to fight cancer. From this perspective and future expected advances, more information is needed such as improved efficacy, methods of application, and the synergistic sensitization of resveratrol as an adjuvant. In addition, resveratrol nanoformulation is considered to overcome its weak bioavailability.
机构:
Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA
VA Med Ctr, Ann Arbor, MI USAUniv Leicester, Dept Canc Studies & Mol Med, LRI,RKCSB, Canc Biomarkers & Prevent Grp, Leicester LE2 7LX, Leics, England
机构:
Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA
VA Med Ctr, Ann Arbor, MI USAUniv Leicester, Dept Canc Studies & Mol Med, LRI,RKCSB, Canc Biomarkers & Prevent Grp, Leicester LE2 7LX, Leics, England