Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)

被引：38

作者：

Yang, H. P. ^{[1
]}

Cook, L. S. ^{[2
]}

Weiderpass, E. ^{[3
,4
,5
,6
]}

Adami, H-O ^{[3
,7
]}

Anderson, K. E. ^{[8
]}

Cai, H. ^{[9
]}

Cerhan, J. R. ^{[10
]}

Clendenen, T. V. ^{[11
,12
]}

Felix, A. S. ^{[1
]}

Friedenreich, C. M. ^{[13
]}

Garcia-Closas, M. ^{[14
]}

Goodman, M. T. ^{[15
]}

Liang, X. ^{[16
]}

Lissowska, J. ^{[17
,18
]}

Lu, L. ^{[19
]}

Magliocco, A. M. ^{[20
,21
]}

McCann, S. E. ^{[22
]}

Moysich, K. B. ^{[22
]}

Olson, S. H. ^{[16
]}

Petruzella, S. ^{[16
]}

Pike, M. C. ^{[16
,23
]}

Polidoro, S. ^{[24
]}

Ricceri, F. ^{[24
]}

Risch, H. A. ^{[19
]}

Sacerdote, C. ^{[24
,25
,26
]}

Setiawan, V. W. ^{[23
]}

Shu, X. O. ^{[9
]}

Spurdle, A. B. ^{[27
]}

Trabert, B. ^{[1
]}

Webb, P. M. ^{[27
]}

Wentzensen, N. ^{[1
]}

Xiang, Y-B ^{[28
]}

Xu, Y. ^{[16
]}

Yu, H. ^{[29
]}

Zeleniuch-Jacquotte, A. ^{[11
,12
]}

Brinton, L. A. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] Univ New Mexico, Albuquerque, NM 87131 USA

[3] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden

[4] Folkhalsan Res Ctr, Dept Genet Epidemiol, Helsinki 00014, Finland

[5] Canc Registry Norway, Dept Res, N-0304 Oslo, Norway

[6] Arctic Univ Norway, Univ Tromso, Dept Community Med, N-90109 Tromso, Norway

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN 55454 USA

[9] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med,Div Epidemiol, Nashville, TN 37232 USA

[10] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

[11] NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA

[12] NYU, Sch Med, NYU Perimutter Canc Ctr, New York, NY 10016 USA

[13] Alberta Hlth Serv, Calgary, AB T2T 5C7, Canada

[14] Inst Canc Res, Sutton SM2 5NG, Surrey, England

[15] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA

[16] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA

[17] M Sklodowska Curie Mem Canc Ctr, PL-02781 Warsaw, Poland

[18] Inst Oncol, PL-02781 Warsaw, Poland

[19] Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT 06510 USA

[20] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[21] Res Inst, Tampa, FL 33612 USA

[22] Roswell Pk Canc Inst, Buffalo, NY 14203 USA

[23] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA

[24] Human Genet Fdn, I-10126 Turin, Italy

[25] Univ Turin, Canc Epidemiol Unit, I-10124 Turin, Italy

[26] Ctr Canc Prevent, I-10124 Turin, Italy

[27] QIMR Berghofer Med Res Inst, Herston, Qld 4029, Australia

[28] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Shanghai Canc Inst, Shanghai 200030, Peoples R China

[29] Univ Hawaii, Ctr Canc, Honolulu, HI 96813 USA

来源：

BRITISH JOURNAL OF CANCER | 2015年 / 112卷 / 05期

基金：

瑞典研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

endometrial cancer; infertility; nulliparity; pooled analysis; POLYCYSTIC-OVARY-SYNDROME; IN-VITRO FERTILIZATION; HOSPITAL DISCHARGE DIAGNOSIS; IOWA WOMENS HEALTH; REPRODUCTIVE FACTORS; GYNECOLOGICAL CONDITIONS; FERTILITY DRUGS; COHORT; BREAST; OVULATION;

D O I：

10.1038/bjc.2015.24

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes. Methods: We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided selfreported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results: Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR = 1.76; 95% CI: 1.59-1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR = 1.22; 95% CI: 1.13-1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer. Conclusions: Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters.

引用

页码：925 / 933

页数：9

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