Flux balance analysis accounting for metabolite dilution

被引：24

作者：

Benyamini, Tomer ^{[1
]}

Folger, Ori ^{[1
]}

Ruppin, Eytan ^{[1
,2
]}

Shlomi, Tomer ^{[3
]}

机构：

[1] Tel Aviv Univ, Blavatnik Sch Comp Sci, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[3] Technion Israel Inst Technol, Dept Comp Sci, IL-32000 Haifa, Israel

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 04期

基金：

以色列科学基金会;

关键词：

ESCHERICHIA-COLI; GEOBACTER-SULFURREDUCENS; BIOMASS COMPOSITION; ESSENTIAL GENES; HIGH-THROUGHPUT; RECONSTRUCTION; NETWORK; GROWTH; MODEL; CAPABILITIES;

D O I：

10.1186/gb-2010-11-4-r43

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.

引用

页数：9

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