Formate and its role in hydrogen production in Escherichia coli

被引：164
作者：
Sawers, RG [1 ]
机构：
[1] John Innes Inst, Dept Mol Microbiol, Norwich NR4 7UH, Norfolk, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2005年 / 33卷
关键词：
formate dehydrogenase; formate hydrogenlyase; formate regulon; formic acid; NiFe-hydrogenase; pyruvate formate-lyase;
D O I：
10.1042/BST0330042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO2 and H-2, has an absolute requirement for formate. Formate, therefore, represents a signature molecule in the fermenting E. coli cell and factors that determine formate metabolism control FHL synthesis and consequently dihydrogen evolution.
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收藏
页码：42 / 46
页数：5
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