Assessment of Oritavancin Serum Protein Binding across Species

被引：17

作者：

Arhin, Francis F. ^{[1
]}

Belley, Adam ^{[1
]}

McKay, Geoffrey ^{[1
]}

Beaulieu, Sylvain ^{[1
]}

Sarmiento, Ingrid ^{[1
]}

Parr, Thomas R., Jr. ^{[1
]}

Moeck, Gregory ^{[1
]}

机构：

[1] Medicines Co, St Laurent, PQ, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 08期

关键词：

STAPHYLOCOCCUS-AUREUS; COMPARATOR AGENTS; PHARMACOKINETICS; ANTIBIOTICS; TEICOPLANIN; CEFTRIAXONE; DAPTOMYCIN; VANCOMYCIN;

D O I：

10.1128/AAC.00271-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Biophysical methods to study the binding of oritavancin, a lipoglycopeptide, to serum protein are confounded by nonspecific drug adsorption to labware surfaces. We assessed oritavancin binding to serum from mouse, rat, dog, and human by a microbiological growth-based method under conditions that allow near-quantitative drug recovery. Protein binding was similar across species, ranging from 81.9% in human serum to 87.1% in dog serum. These estimates support the translation of oritavancin exposure from nonclinical studies to humans.

引用

页码：3481 / 3483

页数：3

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