Oxalyl Amide Assisted Palladium-Catalyzed Arylation of C(sp2)-H Bond at the δ Position

被引：57

作者：

Han, Jian ^{[1
]}

Liu, Pei ^{[1
]}

Wang, Chao ^{[1
]}

Wang, Qian ^{[1
]}

Zhang, Jingyu ^{[1
]}

Zhao, Yanwei ^{[1
]}

Shi, Daqing ^{[1
]}

Huang, Zhibin ^{[1
]}

Zhao, Yingsheng ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 21期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; EFFICIENT SYNTHESIS; C(SP(3))-H BONDS; DIRECTING GROUP; ALKYL; ARYL; CYCLIZATION; ACTIVATION; AMINATION; VERSATILE;

D O I：

10.1021/ol502745g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A successful protocol has been developed for delta-arylation of beta-arylethamines at the ortho position under mild conditions. The newly developed methodology first presents broad substrate scope, great functional group tolerance, and good to excellent yield in the synthesis of substituted beta-arylethylamines. The transformation represents a practical advantage of oxalyl amide in assistance with CH functionalization at a remote position.

引用

页码：5682 / 5685

页数：4

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