MRD response in a refractory paediatric T-ALL patient through anti-programmed cell death 1 (PD-1) Ab treatment associated with induction of fatal GvHD

被引:16
作者
Boekstegers, A-M [1 ]
Blaeschke, F. [1 ]
Schmid, I. [1 ]
Wiebking, V. [1 ]
Immler, S. [1 ]
Hoffmann, F. [1 ]
Bochmann, K. [2 ]
Mueller, S. [3 ]
Gruenewald, T. G. P. [4 ]
Feucht, J. [5 ]
Feuchtinger, T. [1 ]
机构
[1] Ludwig Maximilians Univ Munchen, Childrens Hosp, Dr von Hauner Univ, Dept Paediat Hematol Oncol & Stem Cell Transplant, Munich, Germany
[2] Ludwig Maximilians Univ Munchen, Dept Clin Radiol, Inst Clin Radiol, Munich, Germany
[3] Ludwig Maximilians Univ Munchen, Inst Pathol, Munich, Germany
[4] Ludwig Maximilians Univ Munchen, Max Eder Res Grp Pediat Sarcoma Biol, Inst Pathol, Munich, Germany
[5] Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, 1275 York Ave, New York, NY 10021 USA
关键词
ACUTE LYMPHOBLASTIC-LEUKEMIA; RELAPSE; TRANSPLANTATION; MALIGNANCIES; IPILIMUMAB; LYMPHOMA; BLOCKADE;
D O I
10.1038/bmt.2017.107
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:1221 / 1224
页数:4
相关论文
共 12 条
[1]   Nivolumab in a patient with refractory Hodgkin's lymphoma after allogeneic stem cell transplantation [J].
Angenendt, L. ;
Schliemann, C. ;
Lutz, M. ;
Rebber, E. ;
Schulze, A. B. ;
Weckesser, M. ;
Stegger, L. ;
Schaefers, M. ;
Groth, C. ;
Kessler, T. ;
Lenz, G. ;
Stelljes, M. ;
Berdel, W. E. .
BONE MARROW TRANSPLANTATION, 2016, 51 (03) :443-445
[2]   CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation [J].
Bashey, Asad ;
Medina, Bridget ;
Corringham, Sue ;
Pasek, Mildred ;
Carrier, Ewa ;
Vrooman, Linda ;
Lowy, Israel ;
Solomon, Scott R. ;
Morris, Lawrence E. ;
Holland, H. Kent ;
Mason, James R. ;
Alyea, Edwin P. ;
Soiffer, Robert J. ;
Ball, Edward D. .
BLOOD, 2009, 113 (07) :1581-1588
[3]   Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies [J].
Berger, Raanan ;
Rotem-Yehudar, Rinat ;
Slama, Gideon ;
Landes, Shimon ;
Kneller, Abraham ;
Leiba, Merav ;
Koren-Michowitz, Maya ;
Shimoni, Avichai ;
Nagler, Arnon .
CLINICAL CANCER RESEARCH, 2008, 14 (10) :3044-3051
[4]   Ipilimumab for Patients with Relapse after Allogeneic Transplantation [J].
Davids, Matthew S. ;
Kim, Haesook T. ;
Bachireddy, Pavan ;
Costello, Caitlin ;
Liguori, Rebecca ;
Savell, Alexandra ;
Lukez, Alexander P. ;
Avigan, David ;
Chen, Yi-Bin ;
McSweeney, Peter ;
LeBoeuf, Nicole R. ;
Rooney, Michael S. ;
Bowden, Michaela ;
Zhou, Chensheng W. ;
Granter, Scott R. ;
Hornick, Jason L. ;
Rodig, Scott J. ;
Hirakawa, Masahiro ;
Severgnini, Mariano ;
Hodi, F. Stephen ;
Wu, Catherine J. ;
Ho, Vincent T. ;
Cutler, Corey ;
Koreth, John ;
Alyea, Edwin P. ;
Antin, Joseph H. ;
Armand, Philippe ;
Streicher, Howard ;
Ball, Edward D. ;
Ritz, Jerome ;
Bashey, Asad ;
Soiffer, Robert J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (02) :143-153
[5]   Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97 [J].
Escherich, G. ;
Horstmann, M. A. ;
Zimmermann, M. ;
Janka-Schaub, G. E. .
LEUKEMIA, 2010, 24 (02) :298-308
[6]   T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts [J].
Feucht, Judith ;
Kayser, Simone ;
Gorodezki, David ;
Hamieh, Mohamad ;
Doring, Michaela ;
Blaeschke, Franziska ;
Schlegel, Patrick ;
Bosmuller, Hans ;
Quintanilla-Fend, Leticia ;
Ebinger, Martin ;
Lang, Peter ;
Handgretinger, Rupert ;
Feuchtinger, Tobias .
ONCOTARGET, 2016, 7 (47) :76902-76919
[7]   Minimal residual disease prior to stem cell transplant for childhood acute lymphoblastic leukaemia [J].
Goulden, N ;
Bader, P ;
Van der Velden, V ;
Moppett, J ;
Schilham, M ;
Masden, HO ;
Krejci, O ;
Kreyenberg, H ;
Lankester, A ;
Révész, T ;
Klingebiel, T ;
Van Dongen, J .
BRITISH JOURNAL OF HAEMATOLOGY, 2003, 122 (01) :24-29
[8]   Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia [J].
Schrappe, Martin ;
Hunger, Stephen P. ;
Pui, Ching-Hon ;
Saha, Vaskar ;
Gaynon, Paul S. ;
Baruchel, Andre ;
Conter, Valentino ;
Otten, Jacques ;
Ohara, Akira ;
Versluys, Anne Birgitta ;
Escherich, Gabriele ;
Heyman, Mats ;
Silverman, Lewis B. ;
Horibe, Keizo ;
Mann, Georg ;
Camitta, Bruce M. ;
Harbott, Jochen ;
Riehm, Hansjoerg ;
Richards, Sue ;
Devidas, Meenakshi ;
Zimmermann, Martin .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (15) :1371-1381
[9]   Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study [J].
Schrappe, Martin ;
Valsecchi, Maria Grazia ;
Bartram, Claus R. ;
Schrauder, Andre ;
Panzer-Gruemayer, Renate ;
Moericke, Anja ;
Parasole, Rosanna ;
Zimmermann, Martin ;
Dworzak, Michael ;
Buldini, Barbara ;
Reiter, Alfred ;
Basso, Giuseppe ;
Klingebiel, Thomas ;
Messina, Chiara ;
Ratei, Richard ;
Cazzaniga, Giovanni ;
Koehler, Rolf ;
Locatelli, Franco ;
Schaefer, Beat W. ;
Arico, Maurizio ;
Welte, Karl ;
van Dongen, Jacques J. M. ;
Gadner, Helmut ;
Biondi, Andrea ;
Conter, Valentino .
BLOOD, 2011, 118 (08) :2077-2084
[10]   Fatal GvHD induced by PD-1 inhibitor pembrolizumab in a patient with Hodgkin's lymphoma [J].
Singh, A. K. ;
Porrata, L. F. ;
Aljitawi, O. ;
Lin, T. ;
Shune, L. ;
Ganguly, S. ;
McGuirk, J. P. ;
Abhyankar, S. .
BONE MARROW TRANSPLANTATION, 2016, 51 (09) :1268-1270