Rate of Decline of Kidney Function in Patients With Type 2 Diabetes Mellitus and the Associated Factors: A 10-Year Retrospective Cohort Study

被引：4

作者：

Foon, Tan Siow ^{[1
]}

Chin, Chia Yook ^{[2
]}

Chinna, Karuthan ^{[1
]}

机构：

[1] Univ Malaya, Kuala Lumpur, Malaysia

[2] Curtin Univ, Bentley, WA, Australia

来源：

ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH | 2015年 / 27卷 / 02期

关键词：

decline rate; glomerular filtration rate; retrospective cohort; risk factors; type; 2; diabetes; GLOMERULAR-FILTRATION-RATE; BLOOD-PRESSURE; RENAL-DISEASE; PROGRESSION; NEPHROPATHY; COMPLICATIONS; HYPERTENSION;

D O I：

10.1177/1010539513490193

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study examines the rate of decline of estimated glomerular filtration rate (eGFR) over a 10-year period and the associated risk factors in type 2 diabetes mellitus (T2DM) patients. Medical records of T2DM patients were randomly selected. The rate of fall in eGFR (simplified modification of diet in renal disease formula) was used as a measure of decline. Univariate and multivariate analysis were performed to determine the factors associated with decline of kidney function. A total of 504 patients were selected. Mean age was 57.8 +/- 9 years; 65.3% were females. The mean decline rate of eGFR was 0.89 +/- 2.16 mL/min/1.73 m(2)/y. Baseline proteinuria, glycosylated hemoglobin level, duration of T2DM, and Malay race were associated with faster decline in eGFR. The expected greater deterioration in kidney function in this cohort was not seen. Treatment of proteinuria and glycemia should be optimized early to retard the decline in kidney function in patients with T2DM.

引用

页码：NP640 / NP649

页数：10

共 27 条

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