Synthesis of 7-ethyl-10-hydroxycamptothecin and proposed reaction mechanism

被引：0

作者：

Lei, YJ ^{[1
]}

Zhu, CH ^{[1
]}

Wang, ZQ ^{[1
]}

Liu, H ^{[1
]}

机构：

[1] Xian Modern Chem Res Inst, Xian 710065, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2001年 / 17卷 / 01期

关键词：

7-ethyl-10-hydroxycamptothecin (SN-38); mechanism; synthesis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The improved 3-step preparation of a key antitumor agent, 7-ethyl-10-hydroxycamptothecin (SN-38), which consists of ethylation, oxidation and photo-chemical rearrangement, is described. The proposed reaction mechanism is also discussed.

引用

页码：69 / 72

页数：4

共 7 条

[1] HSIANG YH, 1985, J BIOL CHEM, V260, P4873
[2] PHOTOCHEMICAL REACTION OF 2-CYANOQUINOLINE 1-OXIDES IN AN ACIDIC ALCOHOL - SYNTHESIS OF 6-ALKOXY-2-CYANOQUINOLINES
KANEKO, C
HASEGAWA, H
TANAKA, S
SUNAYASH.K
YAMADA, S
[J]. CHEMISTRY LETTERS, 1974, (02) : 133 - 136
[3] MOERTEL CG, 1972, CANCER CHEMOTH REP 1, V56, P95
[4] MUGGIA FM, 1972, CANCER CHEMOTH REP 1, V56, P515
[5] SAWADA S, 1991, CHEM PHARM BULL, V39, P1446
[6] PLANT ANTITUMOR AGENTS .I. ISOLATION AND STRUCTURE OF CAMPTOTHECIN A NOVEL ALKALOIDAL LEUKEMIA AND TUMOR INHIBITOR FROM CAMPTOTHECA ACUMINATA
WALL, ME
WANI, MC
COOK, CE
PALMER, KH
MCPHAIL, AT
SIM, GA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1966, 88 (16) : 3888 - 3890
[7] YOU QD, 1994, J CHINESE PHARM IND, V25, P250

← 1 →