United Kingdom immune thrombocytopenia registry: retrospective evaluation of bone marrow fibrosis in adult patients with primary immune thrombocytopenia and correlation with clinical findings

被引：24
作者：
Rizvi, Hasan [1 ,2 ]
Butler, Tom [2 ,3 ]
Calaminici, Mariarita [1 ,2 ]
Doobaree, Indraraj U. [2 ]
Nandigam, Raghava C. [2 ]
Bennett, Dimitri [4 ]
Provan, Drew [2 ]
Newland, Adrian C. [2 ,3 ]
机构：
[1] Queen Mary Univ, Barts Hlth NHS Trust, Dept Pathol, London, England
[2] Queen Mary Univ, Barts & London Sch Med & Dent, London, England
[3] Bart Hlth NHS Trust, Dept Haematol, London, England
[4] GlaxoSmithkline R&D, WW Epidemiol Dept, Philadelphia, PA USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2015年 / 169卷 / 04期
关键词：
primary immune thrombocytopenia; bone marrow fibrosis; reticulin fibrosis; collagen fibrosis; co-morbidities; LONG-TERM; RETICULIN; EFFICACY; SAFETY;
D O I：
10.1111/bjh.13330
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fibrosis has been reported in some patients with immune thrombocytopenia (ITP) treated with thrombopoietin receptor agonists (TPO-RA). However, fibrosis has also been reported in patients with various stages of ITP, who were TPO-RA treatment-naive. In our study, we looked for fibrosis in bone marrow trephine biopsies taken at initial diagnosis from 32 adult patients with ITP. Ten of the 32 evaluated samples (3125%) showed increased reticulin (Grade 1-2 on Bauermeister scale and Grade 0-1 on the European Consensus scale), which showed a positive correlation with ethnicity (03%) but did not correlate with disease severity, any clinical features or co-morbidities.
引用
收藏
页码：590 / 594
页数：5
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