The biology of natural killer cells during sepsis

被引:96
作者
Guo, Yin [1 ,2 ]
Patil, Naeem K. [1 ]
Luan, Liming [1 ]
Bohannon, Julia K. [1 ]
Sherwood, Edward R. [1 ,2 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Anesthesiol, Nashville, TN USA
[2] Vanderbilt Univ, Med Ctr, Dept Pathol Microbiol & Immunol, Nashville, TN USA
基金
美国国家卫生研究院;
关键词
inflammation; innate lymphoid cells; natural killer cell; sepsis; CHRONIC CRITICAL ILLNESS; IFN-GAMMA PRODUCTION; DISSEMINATED INTRAVASCULAR COAGULATION; BETA-2-MICROGLOBULIN KNOCKOUT MICE; INNATE LYMPHOID-CELLS; NK CELLS; SEPTIC SHOCK; INTERFERON-GAMMA; SYSTEMIC INFLAMMATION; IMMUNE DYSFUNCTION;
D O I
10.1111/imm.12854
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer (NK) cells are large granular lymphocytes largely recognized for their importance in tumour surveillance and the host response to viral infections. However, as the major innate lymphocyte population, NK cells also coordinate early responses to bacterial infections by amplifying the antimicrobial functions of myeloid cells, especially macrophages, by production of interferon-gamma (IFN-gamma). Alternatively, excessive NK cell activation and IFN-gamma production can amplify the systemic inflammatory response during sepsis resulting in increased physiological dysfunction and organ injury. Our understanding of NK cell biology during bacterial infections and sepsis is mostly derived from studies performed in mice. Human studies have demonstrated a correlation between altered NK cell functions and outcomes during sepsis. However, mechanistic understanding of NK cell function during human sepsis is limited. In this review, we will review the current understanding of NK cell biology during sepsis and discuss the challenges associated with modulating NK cell function during sepsis for therapeutic benefit.
引用
收藏
页码:190 / 202
页数:13
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