Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma?

被引：31

作者：

Baek, R. ^{[1
]}

Varming, K. ^{[1
]}

Jorgensen, M. M. ^{[1
]}

机构：

[1] Aalborg Univ Hosp, Dept Clin Immunol, Urbansgade 32-36, DK-9000 Aalborg, Denmark

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2016年 / 55卷 / 01期

关键词：

Extracellular vesicles in plasma; Phenotyping; Smoking; Aging; Gender; SOLUBLE CD146; EXOSOMES; EXPRESSION; CANCER; MUC18; MACROPHAGES; MARKERS; CELLS; FLUID; GENE;

D O I：

10.1016/j.transci.2016.07.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Extracellular vesicles (EVs) are involved in several diseases, which have formed the basis for the potential use of EV analyses in a clinical setting. The protein phenotype of EVs can provide information on the functionality of the vesicles and may be used for identification of disease-related biomarkers. With this extensive study of 161 healthy individuals it was elucidated that certain markers of plasma EVs are influenced by demographic variations such as gender, age and smoking status. When the purpose is to use EVs as a diagnostic tool, it should be emphasized how important it is to choose the correct demographic group when comparing marker levels of plasma EVs. (C) 2016 The Authors. Published by Elsevier Ltd.

引用

页码：44 / 52

页数：9

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