Thyroid hormone-responsive genes mediate otolith growth and development during flatfish metamorphosis
被引:12
作者:
Wang, X.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Wang, X.
[2
]
Tan, Y.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Tan, Y.
[2
]
Sievers, Q.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Sievers, Q.
[2
]
Sievers, B.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Sievers, B.
[2
]
Lee, M.
论文数: 0引用数: 0
h-index: 0
机构:
Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Lee, M.
[2
]
Burrall, K.
论文数: 0引用数: 0
h-index: 0
机构:
St Lawrence Univ, Dept Biol, Canton, NY 13617 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Burrall, K.
[1
]
Schreiber, A. M.
论文数: 0引用数: 0
h-index: 0
机构:
St Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USASt Lawrence Univ, Dept Biol, Canton, NY 13617 USA
Schreiber, A. M.
[1
,2
]
机构:
[1] St Lawrence Univ, Dept Biol, Canton, NY 13617 USA
[2] Carnegie Inst, Dept Embryol, Baltimore, MD 21210 USA
Flatfish begin life as up-right swimming, bilaterally symmetrical larvae that metamorphose into asymmetrically shaped juveniles that swim with a highly lateralized posture. We have previously shown that TH induces abrupt growth and mineralization of one component of the vestibular system, the otoliths, during early larval development and metamorphosis. Here we report that four of five vestibular-specific genes that we tested (alpha-tectorin, otogelin, otolith matrix protein, and otopetrins I and 2 that are known to be associated with otolith development in other vertebrates are up-regulated 1.5- to 7-fold in larval flatfish during spontaneous metamorphosis and/or following 72 h of TH treatment. These findings suggest that otolith growth and development are mediated by diverse TH-responsive genes during flatfish metamorphosis. (C) 2010 Elsevier Inc. All rights reserved.