TRAIL Modulates the Immune System and Protects against the Development of Diabetes

被引：33

作者：

Bossi, Fleur ^{[1
]}

Bernardi, Stella ^{[1
]}

Zauli, Giorgio ^{[2
]}

Secchiero, Paola ^{[3
]}

Fabris, Bruno ^{[1
]}

机构：

[1] Univ Trieste, Cattinara Univ Hosp, Dept Med Surg & Hlth Sci, I-34100 Trieste, Italy

[2] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34100 Trieste, Italy

[3] Univ Ferrara, LTTA Ctr, Dept Morphol Surg & Expt Med, I-44100 Ferrara, Italy

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2015年 / 2015卷

关键词：

APOPTOSIS-INDUCING LIGAND; C-REACTIVE PROTEIN; T-CELL-ACTIVATION; NF-KAPPA-B; ADIPOSE-TISSUE; INSULIN-RESISTANCE; THYMOCYTE APOPTOSIS; MEDIATED ACTIVATION; ENDOTHELIAL-CELLS; ADIPOCYTE DEATH;

D O I：

10.1155/2015/680749

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TRAIL or tumor necrosis factor (TNF) related apoptosis-inducing ligand is a member of the TNF superfamily of proteins, whose best characterized function is the induction of apoptosis in tumor, infected, or transformed cells through activation of specific receptors. In nontransformed cells, however, the actions of TRAIL are less well characterized. Recent studies suggest that TRAIL may be implicated in the development and progression of diabetes. Here we review TRAIL biological actions, its effects on the immune system, and how and to what extent it has been shown to protect against diabetes.

引用

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