A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Diseases

被引：37
作者：
Martinez, Carmen [1 ,2 ]
Juarranz, Yasmina [1 ,2 ]
Gutierrez-Canas, Irene [1 ,2 ]
Carrion, Mar [1 ,2 ]
Perez-Garcia, Selene [1 ,2 ]
Villanueva-Romero, Raul [1 ,2 ]
Castro, David [1 ,2 ]
Lamana, Amalia [1 ,2 ]
Mellado, Mario [3 ]
Gonzalez-Alvaro, Isidoro [4 ]
Gomariz, Rosa P. [1 ,2 ]
机构：
[1] Univ Complutense Madrid, Dept Biol Celular, Fac Biol, E-28040 Madrid, Spain
[2] Univ Complutense Madrid, Fac Med, E-28040 Madrid, Spain
[3] CSIC, Dept Inmunol & Oncol, CNB, Madrid 28049, Spain
[4] Hosp Univ La Princesa, Inst Invest Med, Serv Reumatol, Madrid 28006, Spain
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 01期
关键词：
vasoactive intestinal peptide; VPAC1; receptor; VPAC2; rheumatic diseases; inflammatory bowel disease; central nervous system diseases; type; 1; diabetes; Sjogren's syndrome; biomarkers; VASOACTIVE-INTESTINAL-PEPTIDE; CYCLASE-ACTIVATING POLYPEPTIDE; TOLL-LIKE RECEPTORS; PATTERN-RECOGNITION RECEPTORS; RHEUMATOID SYNOVIAL FIBROBLASTS; TOLEROGENIC DENDRITIC CELLS; PROTEIN-COUPLED RECEPTOR; GENE-RELATED PEPTIDE; REGULATORY T-CELLS; SUBSTANCE-P;
D O I：
10.3390/ijms21010065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenous neuropeptide produced by neurons and endocrine and immune cells, involved in the control of both innate and adaptive immune responses. Exogenous administration of VIP exerts therapeutic effects in models of autoimmune/inflammatory diseases mediated by G-protein-coupled receptors (VPAC1 and VPAC2). Currently, there are no curative therapies for inflammatory and autoimmune diseases, and patients present complex diagnostic, therapeutic, and prognostic problems in daily clinical practice due to their heterogeneous nature. This review focuses on the biology of VIP and VIP receptor signaling, as well as its protective effects as an immunomodulatory factor. Recent progress in improving the stability, selectivity, and effectiveness of VIP/receptors analogues and new routes of administration are highlighted, as well as important advances in their use as biomarkers, contributing to their potential application in precision medicine. On the 50th anniversary of VIP's discovery, this review presents a spectrum of potential clinical benefits applied to inflammatory and autoimmune diseases.
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页数：41
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