Binary switches and modification cassettes in histone biology and beyond

被引：526

作者：

Fischle, W ^{[1
]}

Wang, YM ^{[1
]}

Allis, CD ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromat Biol, New York, NY 10021 USA

来源：

NATURE | 2003年 / 425卷 / 6957期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature02017

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An immense number of post-translational modifications on histone proteins have been described and additional sites of modification are still being uncovered. Whereas many direct and indirect connections between certain histone modifications and distinct biological phenomena have now been established, concepts for comprehending the extreme density and variety of these covalent modifications are lacking. Here, we formally introduce localized 'binary switches' and 'modification cassettes' as new concepts in histone biology, elucidating mechanisms that might govern the biological readout of distinct modification patterns. Specifically, our hypotheses provide missing models for the dynamic readout of stable histone modifications and offer explanations for several long-standing questions embedded in the literature. Our ideas might also apply to non-histone proteins and are open to direct experimental examination.

引用

页码：475 / 479

页数：5

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