Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo

被引：245

作者：

Millan, MJ ^{[1
]}

Dekeyne, A ^{[1
]}

Gobert, A ^{[1
]}

机构：

[1] Inst Rech Servier, Dept Psychopharmacol, F-78290 Paris, France

来源：

NEUROPHARMACOLOGY | 1998年 / 37卷 / 07期

关键词：

5-HT2C; receptors; monoamines; dialysis; frontal cortex;

D O I：

10.1016/S0028-3908(98)00078-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The novel, preferential 5-HT2C receptor agonist; Ro 60-0175 ((S)-2-(6-chloro-5-fluoroindol-1-yl)-1-metllylethylamine) (2.5 mg/kg, s.c.), markedly suppressed dialysate levels of dopamine (DA) and noradrenaline (NA) levels in the frontal cortex of freely-moving rats without affecting levels of 5-HT. In contrast, the novel and selective 5-HT2C receptor antagonist, SB-242084 (6-chloro-5-methyl-1-[6-(2-methylpyridin-3-yloxy) pyridin-3-yl carbamoyl] indoline) (10.0 mg/kg, i.p.), markedly increased dialysate levels of DA and NA without modifying those of 5-HT. These data suggest that 5-HT2C receptors exert a tonic, inhibitory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission. (C) 1998 Elsevier Science Inc. All rights reserved.

引用

页码：953 / 955

页数：3

共 10 条

[1] Novel agonists of 5HT(2C) receptors. Synthesis and biological evaluation of substituted 2-(indol-1-yl)-1-methylethylamines and 2-(indeno[1,2-b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder [J].

Bos, M ;

Jenck, F ;

Martin, JR ;

Moreau, JL ;

Sleight, AJ ;

Wichmann, J ;

Widmer, U .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (17) :2762-2769

[2] SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist [J].

Kennett, GA ;

Wood, MD ;

Bright, F ;

Trail, B ;

Riley, G ;

Holland, V ;

Avenell, KY ;

Stean, T ;

Upton, N ;

Bromidge, S ;

Forbes, IT ;

Brown, AM ;

Middlemiss, DN ;

Blackburn, TP .

NEUROPHARMACOLOGY, 1997, 36 (4-5) :609-620

[3] Dopamine, the prefrontal cortex and schizophrenia [J].

Knable, MB ;

Weinberger, DR .

JOURNAL OF PSYCHOPHARMACOLOGY, 1997, 11 (02) :123-131

[4]

MD K., 1996, Modul. Dopaminergic Neurotransmission by Other Neurotransmitters, P87

[5] 5-HT2C receptors mediate penile erections in rats: Actions of novel and selective agonists and antagonists [J].

Millan, MJ ;

Peglion, JL ;

Lavielle, G ;

PerrinMonneyron, S .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 325 (01) :9-12

[6]

Millan MJ, 1997, J PHARMACOL EXP THER, V282, P132

[7] SYSTEMIC ADMINISTRATION OF AMPEROZIDE, A NEW ATYPICAL ANTIPSYCHOTIC DRUG, PREFERENTIALLY INCREASES DOPAMINE RELEASE IN THE RAT MEDIAL PREFRONTAL CORTEX [J].

NOMIKOS, GG ;

IURLO, M ;

ANDERSSON, JL ;

KIMURA, K ;

SVENSSON, TH .

PSYCHOPHARMACOLOGY, 1994, 115 (1-2) :147-156

[8] ACTIONS OF 5-HYDROXYTRYPTAMINE ON VENTRAL TEGMENTAL AREA NEURONS OF THE RAT IN-VITRO [J].

PESSIA, M ;

JIANG, ZG ;

NORTH, RA ;

JOHNSON, SW .

BRAIN RESEARCH, 1994, 654 (02) :324-330

[9] DISTRIBUTION OF THE SEROTONIN 5-HT2 RECEPTOR FAMILY MESSENGER-RNAS - COMPARISON BETWEEN 5-HT(2A) AND 5-HT(2C) RECEPTORS [J].

POMPEIANO, M ;

PALACIOS, JM ;

MENGOD, G .

MOLECULAR BRAIN RESEARCH, 1994, 23 (1-2) :163-178

[10] INCREASE OF EXTRACELLULAR DOPAMINE IN THE PREFRONTAL CORTEX - A TRAIT OF DRUGS WITH ANTIDEPRESSANT POTENTIAL [J].

TANDA, G ;

CARBONI, E ;

FRAU, R ;

DICHIARA, G .

PSYCHOPHARMACOLOGY, 1994, 115 (1-2) :285-288

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