Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides

被引：27

作者：

Verma, Piyush Kumar ^{[1
]}

Prasad, K. Sujit ^{[1
]}

Varghese, Dominic ^{[1
]}

Geetharani, K. ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 04期

关键词：

NICKEL-CATALYZED BORYLATION; C-H BORYLATION; ALPHA; BETA-UNSATURATED CARBONYL; ALKYLBORONIC ESTERS; COUPLING REACTIONS; SECONDARY; HALIDES; FUNCTIONALIZATION; HYDROBORATION; REACTIVITY;

D O I：

10.1021/acs.orglett.0c00038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cobalt-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B(2)pin(2) or B(2 )neop(2)) has been developed under mild reaction conditions, demonstrating the first cobalt-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this cobalt-mediated catalytic cycle.

引用

收藏

页码：1431 / 1436

页数：6

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