Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

被引：150

作者：

Goel, Rishi R. ^{[1
,2
]}

Painter, Mark M. ^{[1
,2
,3
]}

Lundgreen, Kendall A. ^{[4
]}

Apostolidis, Sokratis A. ^{[1
,2
,5
]}

Baxter, Amy E. ^{[1
,3
]}

Giles, Josephine R. ^{[1
,3
,6
]}

Mathew, Divij ^{[1
,2
]}

Pattekar, Ajinkya ^{[2
]}

Reynaldi, Arnold ^{[7
]}

Khoury, David S. ^{[7
]}

Gouma, Sigrid ^{[4
]}

Hicks, Philip ^{[4
]}

Dysinger, Sarah ^{[4
]}

Hicks, Amanda ^{[2
]}

Sharma, Harsh ^{[2
]}

Herring, Sarah ^{[2
]}

Korte, Scott ^{[2
]}

Kc, Wumesh ^{[1
,8
]}

Oldridge, Derek A. ^{[1
,9
]}

Erickson, Rachel, I ^{[4
]}

Weirick, Madison E. ^{[4
]}

McAllister, Christopher M. ^{[4
]}

Awofolaju, Moses ^{[4
]}

Tanenbaum, Nicole ^{[4
]}

Dougherty, Jeanette ^{[1
]}

Long, Sherea ^{[1
]}

D'Andrea, Kurt ^{[1
]}

Hamilton, Jacob T. ^{[2
,4
]}

McLaughlin, Maura ^{[1
,3
]}

Williams, Justine C. ^{[2
]}

Adamski, Sharon ^{[2
]}

Kuthuru, Oliva ^{[1
]}

Drapeau, Elizabeth M. ^{[4
]}

Davenport, Miles P. ^{[7
]}

Hensley, Scott E. ^{[4
]}

Bates, Paul ^{[4
]}

Greenplate, Allison R. ^{[1
,2
]}

Wherry, E. John ^{[1
,2
,3
,6
]}

机构：

[1] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Immune Hlth, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Syst Pharmacol & Translat Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Div Rheumatol, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Parker Inst Canc Immunotherapy, Perelman Sch Med, Philadelphia, PA 19104 USA

[7] Univ New South Wales, Kirby Inst, Sydney, NSW, Australia

[8] Univ Penn, Div Cardiovasc Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[9] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

CELL | 2022年 / 185卷 / 11期

基金：

澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

IMMUNITY;

D O I：

10.1016/j.cell.2022.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined antibody and memory B cell responses longitudinally for similar to 9-10 months after primary 2-dose SARS-CoV-2 mRNA vaccination and 3 months after a 3rd dose. Antibody decay stabilized between 6 and 9 months, and antibody quality continued to improve for at least 9 months after 2-dose vaccination. Spike-and RBD-specific memory B cells remained durable over time, and 40%-50% of RBD-specific memory B cells simultaneously bound the Alpha, Beta, Delta, and Omicron variants. Omicron-binding memory B cells were efficiently reactivated by a 3rd dose of wild-type vaccine and correlated with the corresponding increase in neutralizing antibody titers. In contrast, pre-3rd dose antibody titers inversely correlated with the fold-change of antibody boosting, suggesting that high levels of circulating antibodies may limit the added protection afforded by repeat short interval boosting. These data provide insight into the quantity and quality of mRNA-vaccine-induced immunity over time through 3 or more antigen exposures.

引用

页码：1875 / +

页数：21

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