Identifying the origin of local flexibility in a carbohydrate polymer

被引:30
作者
Anggara, Kelvin [1 ]
Zhu, Yuntao [2 ]
Fittolani, Giulio [2 ,3 ]
Yu, Yang [2 ]
Tyrikos-Ergas, Theodore [2 ,3 ]
Delbianco, Martina [2 ]
Rauschenbach, Stephan [1 ,4 ]
Abb, Sabine [1 ]
Seeberger, Peter H. [2 ,3 ]
Kern, Klaus [1 ,5 ]
机构
[1] Max Planck Inst Solid State Res, Nanoscale Sci Dept, D-70569 Stuttgart, Germany
[2] Max Planck Inst Colloids & Interfaces, Biomol Syst Dept, D-14476 Potsdam, Germany
[3] Free Univ Berlin, Dept Chem & Biochem, D-14195 Berlin, Germany
[4] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[5] Ecole Polytech Fed Lausanne, Inst Phys, CH-1015 Lausanne, Switzerland
关键词
structure-property relationship; glycan flexibility; automated synthesis; AMORPHOUS CELLULOSE; CHEMISTRY; MACHINES; DYNAMICS; CRYSTAL; SCIENCE; DESIGN; SPACE; NMR; DNA;
D O I
10.1073/pnas.2102168118
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Correlating the structures and properties of a polymer to its monomer sequence is key to understanding how its higher hierarchy structures are formed and how its macroscopic material properties emerge. Carbohydrate polymers, such as cellulose and chitin, are the most abundant materials found in nature whose structures and properties have been characterized only at the submicrometer level. Here, by imaging single-cellulose chains at the nanoscale, we determine the structure and local flexibility of cellulose as a function of its sequence (primary structure) and conformation (secondary structure). Changing the primary structure by chemical substitutions and geometrical variations in the secondary structure allow the chain flexibility to be engineered at the single-linkage level. Tuning local flexibility opens opportunities for the bottom-up design of carbohydrate materials.
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页数:6
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