Psychological distress and quality of life in Chinese early-stage breast cancer patients throughout chemotherapy

被引:10
作者
Lan, Bo [1 ]
Lv, Dan [1 ]
Yang, Min [2 ]
Sun, Xiaoying [3 ]
Zhang, Li [4 ,5 ]
Ma, Fei [1 ]
机构
[1] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Canc Hosp, Dept Med Oncol,Natl Canc Ctr, Beijing, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Comprehens Oncol Dept,Canc Hosp, Beijing, Peoples R China
[3] Canc Hosp Huanxing Chaoyang Dist, Dept Med Oncol, Beijing, Peoples R China
[4] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Natl Clin Res Ctr Canc, Shenzhen, Peoples R China
[5] Chinese Acad Med Sci & Peking Union Med Coll, Shenzhen Hosp, Shenzhen, Peoples R China
来源
JOURNAL OF THE NATIONAL CANCER CENTER | 2022年 / 2卷 / 03期
关键词
Anxiety; Depression; Breast cancer; Quality of life; Social support; STEREOTACTIC-BODY-RADIATION; UNRESECTABLE LIVER METASTASES; PHASE-I/II TRIAL; RADIOFREQUENCY ABLATION; LOCAL-CONTROL; I TRIAL; THERAPY; RADIOTHERAPY; SBRT; OUTCOMES;
D O I
10.1016/j.jncc.2022.06.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Breast cancer survivors with psychological problems have higher mortality than those without. Therefore, it is important to monitor and manage their psychological status. This study mainly aimed to dynam-ically estimate the prevalence of anxiety and depression and to clarify the factors associated with anxiety and depression of patients undergoing adjuvant chemotherapy. The secondary objective was to investigate the rela-tionship between depression and anxiety and quality of life (QOL) in Chinese early-stage breast cancer patients.Methods: In a prospective observational single-center cohort study with early-stage breast cancer patients ( n = 290), depression and anxiety severity, QOL, and social support were measured using the Hospital Anxiety and Depression Scale (HADS), the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) scale, and the Chinese version of the Social Support Rating Scale (SSRS), respectively. Canonical correlations were applied to identify correlates between anxiety and depression and demographic and clinical variables. One-way repeated measure analysis of covariance (RMANCOVA) was used to analyze dynamic changes in anxiety, depression, and QOL. Relationships between anxiety and depression and QOL were analyzed using two-way RMANCOVA.Results: The overall anxiety and depression prevalence rates were 35.2% and 44.1%, respectively. Age ( P = 0.042), surgical method ( P = 0.009), social support ( P = 0.001), and breast cancer family history ( P = 0.045) were signifi-cantly associated with depression. The number of children ( P = 0.048) was significantly associated with anxiety. FACT-B scores differed between anxiety and depression and nonanxiety and depression groups, and patients with higher HADS depression and anxiety scores had lower FACT-B scores during chemotherapy ( P < 0.001).Conclusions: We observed dynamic changes in anxiety and depression and QOL and associated factors of anxiety and depression. These findings can provide guidance for psychological monitoring and support for breast cancer patients during the postoperative chemotherapy period.
引用
收藏
页码:155 / 161
页数:7
相关论文
共 51 条
[1]   Stereotactic Body Radiotherapy for Liver Metastases [J].
Aitken, K. L. ;
Hawkins, M. A. .
CLINICAL ONCOLOGY, 2015, 27 (05) :307-315
[2]  
Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
[3]  
Cazic Dejan, 2020, Acta Med Acad, V49, P225, DOI 10.5644/ama2006-124.311
[4]   Stereotactic Body Radiotherapy for Colorectal Liver Metastases A Pooled Analysis [J].
Chang, Daniel T. ;
Swaminath, Anand ;
Kozak, Margaret ;
Weintraub, Julie ;
Koong, Albert C. ;
Kim, John ;
Dinniwell, Rob ;
Brierley, James ;
Kavanagh, Brian D. ;
Dawson, Laura A. ;
Schefter, Tracey E. .
CANCER, 2011, 117 (17) :4060-4069
[5]   NRG Oncology Survey on Practice and Technology Use in SRT and SBRT Delivery [J].
Chetvertkov, Mikhail ;
Monroe, James Ira ;
Boparai, Jaskaran ;
Solberg, Timothy D. ;
Pafundi, Deanna H. ;
Ruo, Russell L. ;
Gladstone, David J. ;
Yin, Fang-Fang ;
Chetty, Indrin J. ;
Benedict, Stanley ;
Followill, David S. ;
Xiao, Ying ;
Sohn, Jason W. .
FRONTIERS IN ONCOLOGY, 2020, 10
[6]   Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies [J].
Dawson, LA ;
McGinn, CJ ;
Normolle, D ;
Ten Haken, RK ;
Walker, S ;
Ensminger, W ;
Lawrence, TS .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (11) :2210-2218
[7]   Stereotactic body radiation therapy for liver metastases: Clinical outcomes and literature review [J].
de la Pena, Cuauhtemoc ;
Gonzalez, Maria F. ;
Gonzalez, Cesar ;
Salazar, Joel M. ;
Cruz, Benjamin .
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2020, 25 (04) :637-642
[8]   The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology [J].
Finkelstein, Steven Eric ;
Timmerman, Robert ;
McBride, WilliamH. ;
Schaue, Doerthe ;
Hoffe, Sarah E. ;
Mantz, Constantine A. ;
Wilson, George D. .
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2011,
[9]   Long-Term Results of a Phase 1 Dose-Escalation Trial and Subsequent Institutional Experience of Single-Fraction Stereotactic Ablative Radiation Therapy for Liver Metastases [J].
Folkert, Michael R. ;
Meyer, Jeffrey J. ;
Aguilera, Todd A. ;
Yokoo, Takeshi ;
Sanford, Nina N. ;
Rule, William G. ;
Mansour, John ;
Yopp, Adam ;
Polanco, Patricio ;
Hannan, Raquibul ;
Nedzi, Lucien A. ;
Timmerman, Robert D. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2021, 109 (05) :1387-1395
[10]   Predictive factors for survival of oligometastatic colorectal cancer treated with Stereotactic body radiation therapy [J].
Franzese, Ciro ;
Comito, Tiziana ;
Toska, Eno ;
Tozzi, Angelo ;
Clerici, Elena ;
De Rose, Fiorenza ;
Franceschini, Davide ;
Navarria, Pierina ;
Reggiori, Giacomo ;
Tomatis, Stefano ;
Scorsetti, Marta .
RADIOTHERAPY AND ONCOLOGY, 2019, 133 :220-226