Tandem [4+1+1] annulation and metal-free aerobic oxidative aromatization: straightforward synthesis of highly substituted phenols from one aldehyde and two ketones

被引：28

作者：

Wang, Mang ^{[1
]}

Fu, Zhenqian ^{[1
]}

Feng, Hui ^{[1
]}

Dong, Ying ^{[1
]}

Liu, Jun ^{[1
]}

Liu, Qun ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 47期

关键词：

ORGANIC-SYNTHESIS; MULTICOMPONENT REACTIONS; CATALYZED OXIDATION; CARBENE COMPLEXES; BENZANNULATION; TERPHENYLS; MIGRATION; CHEMICALS; STRATEGY; ACIDS;

D O I：

10.1039/c0cc02313b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polysubstituted phenols are efficiently assembled from one aldehyde and two different methyl ketones in a one-pot operation via a newly base-induced regiospecific [4 + 1 + 1] annulation and sequential metal-free oxidative aromatization using molecular oxygen (from air) as the sole oxidant at room temperature.

引用

页码：9061 / 9063

页数：3

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