CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases

被引：28
作者：
Nunes, JA
Battifora, M
Woodgett, JR
Truneh, A
Olive, D
Cantrell, DA
机构：
[1] IMPERIAL CANC RES FUND,LYMPHOCYTE ACTIVAT LAB,LONDON WC2A 3PX,ENGLAND
[2] INSERM,U119,F-13009 MARSEILLE,FRANCE
[3] ONTARIO CANC INST,TORONTO,ON M4X 1K9,CANADA
[4] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406
来源：
MOLECULAR IMMUNOLOGY | 1996年 / 33卷 / 01期
关键词：
B7-1; B7-2; signal transduction; Jun kinases;
D O I：
10.1016/0161-5890(95)00121-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present study compares the mitogen-activated protein (MAP) kinase responses in T cells activated with the CD28 ligands B7-1 (CD80) and B7-2/B70 (CD86). Ligands B7-1 and B7-2 do not activate the Raf-1/ERK2 cascade, but share the ability to activate related Jun kinases. These natural ligands for CD28 had no stimulatory effect alone on Jun kinase activation, but the data show that B7-1 and B7-2 could both co-operate with intracellular Ca2+ increase and protein kinase C (PKC) activation to stimulate Jun kinases. The present study shows that the interaction of CD28 with its ligands B7-1 and B7-2 can induce identical signal transduction through the MAP kinase cascades.
引用
收藏
页码：63 / 70
页数：8
相关论文
共 39 条
[1]   B70 ANTIGEN IS A 2ND LIGAND FOR CTLA-4 AND CD28 [J].
AZUMA, M ;
ITO, D ;
YAGITA, H ;
OKUMURA, K ;
PHILLIPS, JH ;
LANIER, LL ;
SOMOZA, C .
NATURE, 1993, 366 (6450) :76-79
[2]   B70/B7-2 IS IDENTICAL TO CD86 AND IS THE MAJOR FUNCTIONAL LIGAND FOR CD28 EXPRESSED ON HUMAN DENDRITIC CELLS [J].
CAUX, C ;
VANBERVLIET, B ;
MASSACRIER, C ;
AZUMA, M ;
OKUMURA, K ;
LANIER, LL ;
BANCHEREAU, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (05) :1841-1847
[3]   CONTINGENT GENETIC REGULATORY EVENTS IN LYMPHOCYTE-T ACTIVATION [J].
CRABTREE, GR .
SCIENCE, 1989, 243 (4889) :355-361
[4]  
DAI TN, 1995, ONCOGENE, V10, P849
[5]   JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN [J].
DERIJARD, B ;
HIBI, M ;
WU, IH ;
BARRETT, T ;
SU, B ;
DENG, TL ;
KARIN, M ;
DAVIS, RJ .
CELL, 1994, 76 (06) :1025-1037
[6]   INDEPENDENT HUMAN MAP KINASE SIGNAL-TRANSDUCTION PATHWAYS DEFINED BY MEK AND MKK ISOFORMS [J].
DERIJARD, B ;
RAINGEAUD, J ;
BARRETT, T ;
WU, IH ;
HAN, JH ;
ULEVITCH, RJ ;
DAVIS, RJ .
SCIENCE, 1995, 267 (5198) :682-685
[7]   THE B7-2 (B70) COSTIMULATORY MOLECULE EXPRESSED BY MONOCYTES AND ACTIVATED B-LYMPHOCYTES IS THE CD86 DIFFERENTIATION ANTIGEN [J].
ENGEL, P ;
GRIBBEN, JG ;
FREEMAN, GJ ;
ZHOU, LJ ;
NOZAWA, Y ;
ABE, M ;
NADLER, LM ;
WAKASA, H ;
TEDDER, TF .
BLOOD, 1994, 84 (05) :1402-1407
[8]   UNCOVERING OF FUNCTIONAL ALTERNATIVE CTLA-4 COUNTER-RECEPTOR IN B7-DEFICIENT MICE [J].
FREEMAN, GJ ;
BORRIELLO, F ;
HODES, RJ ;
REISER, H ;
HATHCOCK, KS ;
LASZLO, G ;
MCKNIGHT, AJ ;
KIM, J ;
DU, LN ;
LOMBARD, DB ;
GRAY, GS ;
NADLER, LM ;
SHARPE, AH .
SCIENCE, 1993, 262 (5135) :907-909
[9]   CLONING OF B7-2 - A CTLA-4 COUNTER-RECEPTOR THAT COSTIMULATES HUMAN T-CELL PROLIFERATION [J].
FREEMAN, GJ ;
GRIBBEN, JG ;
BOUSSIOTIS, VA ;
NG, JW ;
RESTIVO, VA ;
LOMBARD, LA ;
GRAY, GS ;
NADLER, LM .
SCIENCE, 1993, 262 (5135) :909-911
[10]   B7-1 AND B7-2 DO NOT DELIVER IDENTICAL COSTIMULATORY SIGNALS, SINCE B7-2 BUT NOT B7-1 PREFERENTIALLY COSTIMULATES THE INITIAL PRODUCTION OF IL-4 [J].
FREEMAN, GJ ;
BOUSSIOTIS, VA ;
ANUMANTHAN, A ;
BERNSTEIN, GM ;
KE, XY ;
RENNERT, PD ;
GRAY, GS ;
GRIBBEN, JG ;
NADLER, LM .
IMMUNITY, 1995, 2 (05) :523-532
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