Influence of vitamin E acetate on stratum corneum hydration

被引：0

作者：

Gehring, W ^{[1
]}

Fluhr, J ^{[1
]}

Gloor, M ^{[1
]}

机构：

[1] Stadt Klinikum Karlsruhe, Hautklin, D-76133 Karlsruhe, Germany

来源：

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH | 1998年 / 48卷 / 07期

关键词：

CAS; 10191-41-0; stratum corneum; hydration; tocopherol; vitamin E; O/W and W/O emulsion; water-binding capacity;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of vitamin E (tocopherol, CAS 10191-41-0) on stratum corneum hydration was tested in O/W and W/O emulsions. Additionally, the O/W emulsion was used in an in vivo/in vitro method to gravimetrically obtain evidence concerning the water-binding capacity of the stratum corneum. In the W/O emulsion, 2.5 %, 5 %, and 7.5 % vitamin E were compared. With both types of emulsions, vitamin E increased the stratum corneum hydration statistically significantly (p = 0.0002). In addition, we could provide evidence of an enhanced water-binding capacity after treatment with vitamin E (p = 0.05). For the hydrating effect of vitamin E, its concentration is of importance. The optimum concentration turned out to be 5 %.

引用

页码：772 / 775

页数：4