Can we design a better anti-cytokine therapy?

被引：19

作者：

Drutskaya, Marina S. ^{[1
,2
]}

Efimov, Grigory A. ^{[1
,3
]}

Kruglov, Andrei A. ^{[1
,2
,4
]}

Nedospasov, Sergei A. ^{[1
,2
,4
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Vavilov St 32, Moscow 119991, Russia

[2] Lomonosov Moscow State Univ, Moscow, Russia

[3] Natl Res Ctr Hematol, Moscow, Russia

[4] German Rheumatism Res Ctr DRFZ, Berlin, Germany

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2017年 / 102卷 / 03期

基金：

俄罗斯科学基金会;

关键词：

TNF; IL-6; MYSTI; trans-signaling; damaged cartilage; TUMOR-NECROSIS-FACTOR; EXPERIMENTAL INFLAMMATORY ARTHRITIS; TYPE-1; MATRIX-METALLOPROTEINASE; HUMAN RHEUMATOID-ARTHRITIS; DENDRITIC CELL NETWORKS; FACTOR-RECEPTOR; TNF-ALPHA; T-CELLS; PROINFLAMMATORY CYTOKINE; FACTOR INHIBITOR;

D O I：

10.1189/jlb.3MA0117-025R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cytokine neutralization is successfully used for treatment of various autoimmune diseases and chronic inflammatory conditions. The complex biology of the two well-characterized proinflammatory cytokines TNF and IL-6 implicates unavoidable consequences when it comes to their global blockade. Because systemic cytokine ablation may result in unwanted side effects, efforts have been made to develop more specific cytokine inhibitors, which would spare the protective immunoregulatory functions of a given cytokine. In this article, we review current research and summarize new strategies for improved anti-TNF and anti-IL-6 biologics, which specifically target only selected parts of the signaling cascades mediated by these ligands.

引用

页码：783 / 790

页数：8

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