Microwave-Assisted Diversity-Oriented Domino Synthesis of Functionalized Nicotinic Acid Derivatives

被引：19
|
作者：
Tejedor, David [1 ,2 ]
Mendez-Abt, Gabriela [1 ,2 ]
Garcia-Tellado, Fernando [1 ,2 ]
机构：
[1] CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Canary Islands, Spain
[2] Inst Canario Invest Canc, Canary Isl, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 34期
关键词：
Domino reactions; Electrocyclic reactions; Microwave chemistry; Nitrogen heterocycles; Nicotinic acid; PYRIDINES; CONSTRUCTION; FACILE; ACCESS; NIACIN;
D O I：
10.1002/ejoc.201001067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The microwave-assisted diversity-oriented domino synthesis of functionalized alkyl nicotinates from propargyl vinyl ethers is described. The domino manifold comprises a complex network of reactions involving at least five distinct chemical steps. The obtained alkyl nicotinates incorporate two diversity points at the ring and one ester functionality as convenient handles for further elaboration.
引用
收藏
页码：6582 / 6587
页数：6
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