CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

被引：78

作者：

Holz, Lauren E. ^{[1
,2
]}

Prier, Julia E. ^{[1
]}

Freestone, David ^{[1
]}

Steiner, Thiago M. ^{[1
]}

English, Kieran ^{[3
,4
]}

Johnson, Darryl N. ^{[1
,2
]}

Mollard, Vanessa ^{[5
]}

Cozijnsen, Anton ^{[5
]}

Davey, Gayle M. ^{[1
]}

Godfrey, Dale, I ^{[1
,2
]}

Yui, Katsuyuki ^{[6
]}

Mackay, Laura K. ^{[1
,2
]}

Lahoud, Mireille H. ^{[7
,8
]}

Caminschi, Irina ^{[7
,8
]}

McFadden, Geoffrey, I ^{[5
]}

Bertolino, Patrick ^{[3
,4
]}

Fernandez-Ruiz, Daniel ^{[1
]}

Heath, William R. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, ARC Ctr Excellence Adv Mol Imaging, Parkville, Vic 3010, Australia

[3] Univ Sydney, Liver Immunol Program, Centenary Inst, Newtown, NSW 2042, Australia

[4] Univ Sydney, AW Morrow Gastroenterol & Liver Ctr, Newtown, NSW 2042, Australia

[5] Univ Melbourne, Sch BioSci, Parkville, Vic 3010, Australia

[6] Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Div Immunol, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

[7] Monash Univ, Infect & Immun Program, Monash Biomed Discovery Inst, Clayton, Vic 3800, Australia

[8] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

CELL REPORTS | 2018年 / 25卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会;

关键词：

NATURAL-KILLER; NONLYMPHOID TISSUE; LOCAL ANTIGEN; NKT CELLS; RM CELLS; IMMUNE; INFECTION; RESPONSES; MICE; MAINTENANCE;

D O I：

10.1016/j.celrep.2018.08.094

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Liver tissue-resident memory T (Trm) cells migrate throughout the sinusoids and are capable of protecting against malaria sporozoite challenge. To gain an understanding of liver Trm cell development, we examined various conditions for their formation. Although liver Trm cells were found in naive mice, their presence was dictated by antigen specificity and required IL-15. Liver Trm cells also formed after adoptive transfer of in vitro-activated but not naive CD8(+) T cells, indicating that activation was essential but that antigen presentation within the liver was not obligatory. These Trm cells patrolled the liver sinusoids with a half-life of 36 days and occupied a large niche that could be added to sequentially without effect on subsequent Trm cell cohorts. Together, our findings indicate that liver Trm cells form as a normal consequence of CD8(+) T cell activation during essentially any infection but that inflammatory and antigenic signals preferentially tailor their development.

引用

页码：68 / +

页数：16

共 59 条

[1] Unraveling the C-reactive Protein Complement-Cascade in Destruction of Red Blood Cells: Potential Pathological Implications in Plasmodium Falciparum Malaria [J].